Now presumed dead, the Charmed Ones have magically changed their appearances and assumed new identities. Phoebe and Piper adapt to a magic-free life, but Paige finds herself fighting the call of her Whitelighter instincts. She eventually gives in, and meets a new young female charge named Billie Jenkins.

Maggie has chicken pox, so Marge throws a "pox party" to help the children of Springfield catch the illness while they are young. During the party, Milhouse's parents get back together. Milhouse does not like this idea, so he and Bart try to break them up. Instead, they break up Marge and Homer.

When the Arlen Bystander gets a new editor, Peggy gets a job writing a household hints column. Except Peggy doesn't know any household hints, so she gets Minh to supply her with housekeeping tips in exchange for the answers to the New York Times crossword puzzles. Meanwhile, Hank makes Bobby get a paper route.

When the CIA organizes a father-son baseball game, Stan is determined to show his co-workers that his son is masculine and athletic. Unfortunately, Steve is a geek, so Stan decides to lie and ditches him. But after getting a taste of his own treatment at work, Stan turns to Steve and his sci-fi knowledge to help capture a cyber-terrorist. Meanwhile, Roger goes incognito in a desperate attempt to interact with humans.

When a young girl is contacted by a man claiming to be her father, Det. Rush and her team reopen a 1988 case of a teenaged boy, killed on the same night the girl was born.

With a familiar killer in their midst, Slokum is forced to get help from an unlikely source. Will the morgue staff be able to stop this killer... again?

The second season picks up where the first left off. Rex is dead, and, new neighbors, the Applewhites have moved in. Gabrielle, Lynette, and Susan attempt to comfort Bree while Phyllis, Rex's mother, arrives on Wisteria Lane. Meanwhile Mike and Susan deal with Zach while Gabrielle struggles with the two men in her life.

When Chris is supposed to be hazed for a school tradition, he runs off to South America; Peter quickly becomes frustrated by his new job at the beer factory.

Picks up where the last episode left off. Meredith attempts to work with Addison Shepherd. George is pimped out to relay the hospital gossip back to Webber. Meredith and Cristina relate at Emerald City Bar about what dating their respective attendings is like. Cristina ponders her relationship with Burke while trying to make a decision. Meredith is devastated by the latest blow to her love life. Meanwhile, Joe the bartender collapses.

When city health inspector Larry Chapel is found dead in an elevator, a quick look into Chapel's home life introduces them to Chapel's recently widowed brother, Evan, and little girl Gwen. Goren isn't very surprised to learn that Nicole Wallace is Evan's fiance as well as the future mother to his little girl. The Major Case detectives soon realize they're off the mark on who they believe is the suspect and Goren's only hope is to get Nicole to help him trap the killer. Logan joins the Major Case squad, but isn't pleased with being relegated to the background while the other detectives solve the cases. Deakins tries to find a partner for him.

Pompey decides to send Caesar another offer in hopes of limiting his power, in which Caesar decides to take some time to think upon the issue, despite Mark Antony's objections. Meanwhile, Lucius Vorenus refuses to allow some thugs to harm a citizen in debt, which causes him trouble in his job as the thugs he threatened worked for the biggest crime boss in Rome. Titus Pullo also is hired as a military tutor for Octavian, though he discovers that Octavian isn't as helpless as he seems to be.

Political commentators begin to criticize Santos' choice of running mate, but Josh remains sure of Leo as his running mate. The investigation into the leak continues and White House Council Babbish interviews C.J. about the investigation. Meanwhile, Donna approaches Josh for a job.

As the Jewish high holy days approach, a near-death experience, coupled with a comment made by his father, leaves Larry wondering if there's more to his identity than he thought. In better news, a sandwich now bears his name, but it's not entirely to his liking.