Major Kira receives a former teacher of hers, now a Vedek, who had been on sabbatical from the University of Bajor. Always travelling and seeking answers, the Vedek brought the Major something that she may find interesting. When she unwraps the gift, she is transported to Empok Nor, Deep Space Nine's sister station, long thought abandoned by the Cardassians. Now, a group of Bajorans have settled there. Worshipping the enemies of the Prophets, the Pah-Wraiths, they now follow their Gods under a new leader: Dukat.

Stardate: 52188.7 Species 6339, as they are known to Seven of Nine, have created a virus designed to attack the Borg. Unfortunately, Voyager finds the delivery vessel, a vinculum, and Seven of Nine becomes infected. This leads to a conflict between Voyager and Species 6339, who want the vinculum back, so it can be used for its original purpose.

Phoebe has a premonition of a woman being murdered, leading the sisters to attempt to stop the rampage of a murderous warlock. Also, Prue casts a truth spell on Andy, in order to gauge his reaction to her secret.

Joey's "semi-date" with Jack prompts a resentful Dawson to join Jen at a bash where he saves her from doing some things she'll regret. Pacey proves his worth when Andie's mom has a psychotic break during their study session. Mitch cannot understand Dawson's views on their divorce.

A gently surreal episode whose humor derives from escalating skewed logic in the Preston Sturges mode: Greg's hostile secretary Marlene (at last the wonderful Yeardley Smith returns!) is offended by her annual staff evaluation as "Satisfactory", while Greg is overjoyed by his "Superior" rating until he learns Pete got the same rating. When Greg confronts his boss, he is driven to desperation by the man's apparent complete inability to discriminate between similar items (Tahiti vs. Buffalo as a honeymoon destination, freshly baked bread vs. moldy supermarket bread), and almost unhinged by the boss's decision to put Pete in charge while he is in medical leave. At the same time Greg must deal with Dharma's impulse decision to open a store without first deciding what she will sell, and the fact that the place quickly becomes packed with people who find Dharma's environment strangely soothing and establish a barter economy amongst themselves. There is of course only one "logical" conclusion

The murder of a corrections officer leads detectives to a women's prison where a guard was linked to an inmate Carmichael put away on drug charges and a confrontation with defense attorney Danielle Melnick.