The teams take off from their Pit Stop, an active volcano at Mirador Cotopaxi. They receive a clue instructing them to travel 7,400 miles to Santiago, Chile and then take a taxi for 17 miles to the headquarters of Codelco. There, the teams take part in a Roadblock that is ultimately rendered largely meaningless when they all make the same flight traveling 230 miles to Chuquicamatta in Calama, Chile. Once at their destination, the teams put on their safety gear and take part in a Detour that requires them to choose between two tasks traditionally involved in Chilean mining operations. The teams then use marked vehicles to travel the treacherous Valley of the Moon before emerging on safer ground and heading for the Pit Stop at the Valley of the Dead. One team makes a crucial mistake by failing to properly read a clue and posted signs regarding a speed limit. Due largely to this mistake, they fall behind and are eliminated from the race.

A shooting has occurred and three people are dead, including an alleged killer and his snake of a defense attorney. Much to one of the victims surprise, he has been declared dead by mistake and sent to the morgue for an autopsy. Unable to speak or move he can only watch as the doctors prepare to do his autopsy.

Tina gets introduced to Jodi, and has second thoughts about leaving the lesbian life behind. Alice and Tasha argue heatedly over politics. Max hires an intern to help him with the workload on OurChart. While Shane and Paige steam up the car windows, and Catherine and Helena make a winning team at the poker tables, the rest of the girls attend the unveiling of Kit's new single at The Planet.

A beautiful vampire named Bianca comes back into Harry's life to call in an old debt and she drags Harry into a tangled web of undead drugs and warring Vampire factions. Events escalate to the point where even the highest levels of the High Council take an interest and Harry may very well be forced to betray Bianca to save himself.

Amid a heated labor dispute, Tyrol asks the imprisoned Baltar for advice. Seelix becomes involved after she is turned down for flight training.