The nine remaining All-Star teams receive a clue that directs them to travel from their Pit Stop at the Valley of the Dead in Chile four miles to a church in the village of San Pedro de Atacama by the same name. There, they find that they must fly 800 miles to Puerto Montt and then drive 30 to fishery in Metri. As teams maneuver for flights, several find themselves behind when they are unable to catch an early flight, but catch a small break when the flight arrives slightly early. At the fishery, one member of each team completes a Roadblock that requires them to transfer fish from one tank to another. Afterwards, the teams travel fifty miles to Petrohue and find La Maquina, a popular spot for adventure spots. All teams take part in a watery Detour and one loses timebut not positionafter neglecting to pick up a clue. Ultimately, one team is unable to make up time after struggling to find the Detour location and is eliminated from the race.

Principal Skinner decides to allow Lisa tutor Cletus's kids instead of them enrolling into Springfield Elementary, but they end up on Krusty's show as a musical act. Bart sees a psychiatrist after telling a scary ghost story in the cafeteria in an a successful attempt to get free food.

The twelve remaining candidates gear up to organize an automobile-themed VIP event. Arrow organized the better event for the win. For their reward, they got to rap with Snoop Dogg. Kinetic went to the boardroom, where Derek was fired for smarting off to Trump, and Jenn was fired for her poor leadership.

Lilly re-opens the 1964 case of a murdered 17-year-old girl who was killed the day after giving birth to a baby girl in a home for unwed mothers.

Rex Van De Kamp (guest star Steven Culp) narrates this episode that focuses on the men of Wisteria Lane. Mike begins to suspect that Ian (guest star Dougray Scott) proposed to Susan so suddenly because he was afraid of the competition. Tom wants to surprise Lynette on their ninth wedding anniversary. While Austin tries to get Julie to forgive him and be his girlfriend again, Danielle learns that she is pregnant. Gabrielle meets Victor Lang (guest star John Slattery), a man running for mayor of Fairview. Edie receives a surprise visit from her son, Travers.

Peter drives Quagmire to work, but ends up messing things up, causing Quagmire to lose his job as a pilot. After not being able find another job, Peter and Cleveland make plans to help him get his old job back. When the plan fails, Quagmire receives advice from his idol, Hugh Hefner.

Jenny and Tina look for the right movie director but butt heads over creative differences. Phyllis' husband drops by unannounced at Alice's place. Bette is falling hard for Jodi and lets her emotions interfere with her work. Kit manages to crack through Papi's hard outer shell with unexpected consequences.

Antony's nature reasserts itself, and challenges his alliance with Octavian. Timon and Levi set themselves against Herod's plans. Servilia's public displays of grief leave Atia unsettled. Gaia uses Pullo's punishment as a weapon against him. His daughter's sudden interest in business matters arouses Vorenus' suspicions. Posca gets married.

When a man with premonitions about his own death seeks Dresden's help, he promptly drops dead in Harry's office. This prompts Harry and Bob to research his strange death, only to discover the man he thought was dead is still alive. Soon Harry finds himself the target of the dark magician responsible and the spells employed triggers a memory for Bob, who recognizes the darkness in the magic all too well.

Kara continues to have dreams about Leoben Conoy and the mandala she painted at her old apartment on Caprica. While on patrol in her Viper, she encounters a Cylon Heavy Raider.
When Tyrol cannot verify Kara's claim that the Cylon ship struck the Viper, Admiral Adama and Lee become concerned about her mental stability.

Holly and William's daughter makes a surprise appearance at Ojai Foods. Sarah makes some poor and hurtful decisions, unleashing a domino effect of pain. Kevin also makes an error in judgment with bad consequences. Holly throws down the gauntlet when she reaches her limit. A double date with Kitty shows a whole new side of the Walkers to Robert.

Elena is frantic when her daughter Sofie goes missing, and the team has a full schedule as they must also search for a missing female tourist named Jenny.