Strenuous events impact all the Camdens as Kevin and Lucy cope with an unexpected tragedy in their young lives. Matters worsen when Lucy convinces her father to let her deliver next Sunday's sermon while she is still in an emotionally unstable condition. Martin frustrates Sandy by suggesting that they get married and build a family for their infant son, then becomes angry when he realizes why Sandy is really holding back. Ruthie is studying in Scotland for the time being, and Annie can't shake the feeling that something is terribly wrong with Eric.

Following her learning that Richard's willingness to embrace life is responsible for his success with women, Christine goes against form and accepts a date from a handsome stranger.

After WCN's aggressive reporter Judy Nash is scooped by a competing news agency, she and Agent Kelton meet to discuss how they can work together to mutually benefit one another. A flashback reveals that Senator Collins has gone above the law before, while his ex-wife, Jessica Nevins, urges him to take a position on the all-important appointment of Supreme Court nominee Judge Rainer. Agents Mei, Kelton and Tyner close in on leads signaling a turn in the investigation.

Still looking for Louis, Alex and Peter follow a lead to New Jersey. Meanwhile, Kate has to deal with the aftermath of an unexpected conflict.

After insulting a customer, Brent finds himself being publically mocked on a morning radio show; the rest of Dog River thinks it's hilarious and believes that it's really Brent on the radio. Lacey inadvertently stumbles onto a new way to increase her business by delivering food, but then finds that it's just a little too successful for her liking. Karen and Davis stage a "work to rule" protest when they don't get raises, but are surprised at just how much work is involved in the rule book.

Ethan's medical knowledge and connections are put to the test when Lina is rushed to the hospital and her twin, Kat, is unable to get an update on her from the staff. Meanwhile, Perry and Holly, who are trying to get their daughter, Oprah, into a prestigious school, have brunch with Kyle who works at the school. While at brunch, Kyle relives how he broke Holly's heart at the prom.

Barney teaches Marshall how to pick up women. When things start to go sour for an awkward Marshall, Barney steps in and wins the women over... for himself. Meanwhile, Lily is back from her art experience. While helping her look for a new apartment, Robin gets sick of hearing about Lily's amazing summer in San Francisco.

In this episode, we are introduced to Peter Petrelli, a young man who dreams of flying, and his brother Nathan, a ruthless politician who thinks that Peter is dreaming his life away. Meanwhile, ordinary people from all around the world are starting to suspect that they have abilities beyond those of normal humans. Artist Isaac Mendez believes that he is painting the future, high school cheerleader Claire Bennet is suddenly able to recover from any wound almost instantly, Japanese businessman Hiro Nakamura tries to convince a friend that he can bend space and time, and single mother Niki Sanders starts seeing strange things in mirrors. Upon learning of his father's death, genetics Professor Mohinder Suresh begins to look into his research for a clue to why he was killed. When he follows his father's trail to New York City, however, Mohinder learns that someone else is on the trail of the same research. Someone who may kill to protect the secrets of the next step in human evolution.

Michael and Lincoln go house-hunting in Utah to find Westmoreland's hidden money; T-Bag shows his particular brand of Southern hospitality; Haywire finally re-surfaces; Sucre finds a familiar face on the road; Mahone's interest in the legend of DB Cooper leads him closer to the escapees.

Charlie finally tells Alan the truth about why he did not marry Mia. Charlie and Alan deal with a noisy neighbor.

Gene Simmons agrees to a day with his biggest fan, which Playboy Radio sets out to find. Shannon thinks Gene looks corny when he gets all dressed up for his hot date. While Gene is on his date, the family gets rid of his clothes.

While transporting evidence back to the lab Calleigh is run off of the road in to a canal and causes the evidence to be compromised. The team must work to find new evidence and find the person responsible after they learn the biker gang is dealing high-tech weapons.

The Studio 60 cast and crew continue to deal with the fallout of Wes' on-air breakdown, as well as adjusting to Matt and Danny's management. Harriet finds out that Matt is sleeping with Jeannie, a cast member and writer. Meanwhile, Jeannie stresses when a sketch she pitched doesn't go over as well as she hoped; and the team scrambles to find a musical guest when the lead singer for The White Stripes catches tonsillitis.

It's election day and the votes are being cast by friend and foe alike. Andy loses some of his toes at the grow house. Nancy tries to make peace with Conrad. She also has to deal with the romance or lack thereof in both of her sons lives. Doug and Celia are having problems in their respective marriages to Dana and Dean.

Tonight conservative pundit Pat Buchanan.

Tonight Stephen welcomes back Arianna Huffington, blogger and author of On Becoming Fearless...in Love, Work, and Life

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