In the premiere of this series it introduces Eric Camden (Stephen Collins) who's a minister and father of five children and is happily married and soon-to-be dog owner. His wife, Annie Camden (Catherine Hicks) is a stay-at-home mom raising their children. Matt Camden (Barry Watson) is the oldest child who has picked up a habit of smoking and not being able to keep a job. Mary Camden (Jessica Biel) is the oldest daughter who likes to play basketball a lot and is having a craving for wanting to kiss a boy.
Lucy Camden (Beverley Mitchell) is the middle child and is hoping to become a woman and getting her period very soon. Simon Camden (David Gallagher) is the youngest son and is hoping to get a dog very soon, even though his parents already told him that he's too young. Ruthie Camden (Mackenzie Rosman) is the youngest child and is a happy and adorable 5 year-old. Also, Annie learns some devastating news when her parents come for a visit as her mother has leukemia.