On the eve of the millennium, Cartman announces that he has gotten his period, and therefore has entered puberty. Actually, it was rectal bleeding resulting from a colon infection. Kenny gets his "period" too, and they plan a New Year's celebration alone. Feeling left out, Kyle lies about getting his period, and joins their "goddess" club. Stan decided to go to Dr. Mephesto for hormones, in order to speed up his development. Meanwhile, the world is focused on South Park, since Jesus resides there. To appease people's expectations of the millennium, Jesus puts on a concert in Las Vegas with Rod Stewart.

A mysterious man appears carrying a sick young woman and tries to persuade the sceptical staff to accompany him on a mercy mission.

Armando increases Betty's salary and calls RAG-TELA to find out about the confusion with her, and demands a 5% discount. Catalina Ángel arrives at Ecomoda to manage public relations for the new collection to be launched. Mario and Armando propose Betty to design the new company, which will have only one owner, she.