Matt (guest-star Barry Watson) returns home to tell Eric and Annie that Sarah has left him and he's dropping out of medical school. Rabbi Glass offers Matt marital advice. Meanwhile, Kevin must decide whether or not to tell a very jealous Lucy that his ex-wife (guest star Mindy Burbano) is in town and they got invited to dinner with her. Martin's aunt (guest star Keri Lynn Pratt) asks Eric to step in and talk Martin into moving to New York with her and Chandler asks Peter how he would feel about Chandler marrying his mother someday. Peter thinks something is amiss when his mother goes out of town for a business trip. Ruthie keeps something from her mother.

The episode featured four sets of twins competing as teams.

When Berta is forced to bring her granddaughter Prudence to work with her, the boys find themselves a little preoccupied with her.

An anesthesiologist who worked in a beauty clinic is discovered swinging from a rope in his two-story condo, but the investigation points to murder, not suicide. The case intensifies when it's learned that the doctor lost a patient the week before during routine plastic surgery and that the victim's husband believes she was killed.

The Montecito is the host for the biggest boxing match of the year. Danny and Ed must keep the fighters' warring entourages from turning the casino into one huge fight. When one of the entourages steals the other fighter's manager's prosthetic leg, Danny must find the leg before the fight or be forced to cancel the main event. The odds on the under card keep fluctuating, causing Ed to get suspicious. They question Colmen Riggs and find out that they may have a huge problem on their hands. Mike, Nessa and Delinda find $50,000 and Mike is convinced they will have a weekend of love.

Chrissie and Mubbs wake up together after their one night stand and Ed Keating finds out that his father will be released in a few weeks.