Annie rushes her husband to the hospital when he wakes up with a certain hunch about his heart condition. The kids are a bundle of nerves - especially Lucy - since they don't know whether the news is good or bad. While sitting around in the waiting room, Ruthie and T-Bone decide to get back together, but an unexpected twist of events brings back unresolved issues with the guy who broke Ruthie's heart a year ago.

The All-Stars final three -- Dustin & Kandice, Eric & Danielle, and Charla & Mirna -- compete in the final leg to determine who will win the one-million-dollar prize. The teams take off from their Pit Stop in Guam and are instructed to fly 3,500 miles to Honolulu, Hawaii. One team secures an early flight, but the advantage is largely neutralized when the teams must sign up for charter flights leaving ten minutes apart in Hawaii. The teams travel to Kaumalapau Harbor via Jeeps and find themselves in involved in a Detour that tests their ability at a skill either above or below water. All teams then travel to Shipwreck Beach and crossing rocky terrain, face a challenging kayaking task to retrieve their next clue. Ultimately, all teams board the flight to Oakland, California, en route to their final destination city of San Francisco. A final task tests the ability of the racers to think like their partners. When one team proves rather more adept at it than the others, it turns out to be advantage they need to secure victory. They cross the finish line in San Francisco's Botanical Garden first and become the winners of The Amazing Race: All Stars.

The team investigates the antibiotic-resistant strain of C.Difficile that killed Carlos' ex-wife, which has been traced to a potted mum grown on a farm in California.

Forest fires in B.C. are releasing deadly toxins consistent with biological terrorism; Bob struggles to stay useful to NORBAC after a diagnosis of stage three glaucoma; Rachel's charismatic son Craig catches the attention of Mayko and Carlos.

Maggie goes on a path of destruction in the Simpsons home after Marge follows advice in Smothering Mother magazine and throws away her pacifier. Marge finally gives in and sends Homer to get Maggie a new pacifier, but when he can't find the right brand, Maggie comes up with her own substitute: an especially squeaky dog toy. Homer can't sleep through the toy's incessant squeaking and is driven to take sleeping pills, which turn him into a sleepwalker with a penchant for mischief. When one of Homer's sleepwalking schemes leaves the entire Springfield Fire Department debilitated in the hospital, Homer and some of his fellow Springfieldians become volunteer firefighters. They extinguish several fires and are rewarded with gifts, but when the gifts stop coming, they seek other forms of compensation for their heroic acts.

Peggy tries to reach the pinnacle of real estate success by selling houses in the exclusive neighborhood of Arlen Heights, but she winds up selling pots door to door. Meanwhile the real Rusty Shackleford pays a visit to Dale.

When Stan brings home CIA equipment designed to eavesdrop on conversations, he finds out that his neighbors don't think too highly of him. In retaliation, Stan has the entire neighborhood evicted so that he can live free of any criticism. However, when an unexpected friend comes to his rescue, he realizes that gossip is a two-way street.

In the fourth season finale, a hostage situation arises when the entire team is held captive while they're investigating the 2006 killings of a family who had just moved into a new house.

Susan goes into the woods to try to find Mike. Gabrielle gets into an argument with a meter man who gives her a ticket. Victor is elected mayor, and Gabrielle goes back to teach the meter man a lesson. Edie's ex-husband comes back to collect Travers. Lynette realizes she has feelings for another man.

After Chris is expelled from school, he is sent to a boarding school that his grandfather Carter attended, but Chris doesn't exactly fit in. Meanwhile, the chicken returns to pick a fight with Peter.

As A.J. struggles with depression over his break up with Blanca, the feud between Christopher and Paulie grows, with Kelli's dad as an unintentional catalyst.

The boys use Bubble's love for model trains when they make a plan to smuggle marijuana across the border into Maine. They send a team consisting of Jacob and his "crew" to scout the location, however the scouting team goes missing.

Gene decides to take his business partner's thirty year old nephew out on the town in Las Vegas to help cheer him up after learning about his divorce. Gene soon finds out that getting game isn't as easy as it used to be.

The vineyard opens up and the whole family attends. Holly also makes a move on Mark when Nora is gone.

Medellin" is back on the table for Vince, but Ari and producer Nick Rubenstein must make the deal happen on the holy day, Yom Kippur, they have until sundown, and must finish the deal without the use of a cell phone; Eric wonders how the relationship between Vince and Amanda is affecting the deal; Drama grows attached to a race horse.

A high school student goes missing after leaving her prom early to get some rest in her hotel room, leaving behind a bloody dress and a lot of questions about what may have happened to her.

Carlos takes on a sensitivity training class. Then the world of speed dating where Carlos dresses as a Latina woman trying to find a mate.

As King Henry gains in confidence, his displeasure with the way the Catholic church handles his request for an annulment of his marriage to Katherine of Aragon grows. As a result, Cardinal Wolsey's position is weakening, leaving him vulnerable to his enemies.

Dangle visits his ex-wife and her new husband on their anniversary. Meanwhile, Trudy, Clementine, Raineesha, and Cheresa stake-out a lecherous Meth Dealer and his girlfriends.

The dead body of pro boxer Diesel Swanson has gone missing. Things get weird when a tape shows Diesel getting up and walking out of the funeral home.

Vicki attempts to drive a car as it travels along under a lorry. Tiff races against the current World Superbike Champion, James Toseland.

The team reinvestigates the 1950s murder of a young wages clerk at Battersea Power Station.
Richard Dunne was hanged for Frederick Tully's murder, but his granddaughter, Hannah, is waging a campaign to have Dunne posthumously pardoned.
The discovery of a suitcase containing used fivers in the attic of the Tully home sheds new light on the case, revealing a possible blackmail plot.
A trace on the used fivers reveals that they should have been destroyed in the Battersea Power Station furnaces back in the 1950s, but were actually being saved by Douglas Murray, a friend of Tully's.
It also becomes clear that the Battersea furnaces were being used to destroy other sensitive documents as well as used bank notes.
When the team discovers a classified document relating to a massacre of civilians carried out by the British Army in Kenya, they uncover a blackmail plot spanning more than 50 years.