Homer surprises Marge with a visit to her favorite childhood vacation spot: an island called Barnacle Bay. But when the family arrives, they are shocked to discover Barnacle Bays tourism and economy has been decimated by the disappearance of the local delicacy, the Yum-Yum fish. After causing some major damage to the boardwalk, Homer is forced to join a fishing crew to work off his debt and a parody of The Perfect Storm ensues.

When Stan enters an essay contest to have his personal hero, President Bush, come over for dinner, he is overcome with joy when the President arrives at his doorstep. However, not everyone in the Smith family shares Stan's excitement. Hayley tries to drill President Bush on the Iraq war, and Steve and Roger attempt to convince him that they've found Osama Bin Laden, but instead get him drunk. Stan tries to save the President from public humiliation, while Hayley revels in his fall from glory.

The Apprentice moves to Los Angeles, and eighteen new candidates vie for a coveted position with Donald Trump in this sixth season.
In the season premiere, all of the candidates worked together to put up a large tent in an opening task that determined the two first team leaders and Project Managers -- Heidi and Frank. The two teams then competed to see who would make more money running a car wash. Heidi's team ended up bringing in more money for the win. They were treated to dinner at Spago with Trump and Melania for their reward. Frank's team went to the boardroom, where he was nearly fired for his bad leadership, but Martin was fired instead for not really doing all that much for the team and really not fitting the mold of what Trump thinks an Apprentice should be.

When a video clip of a missing student is found on the Internet, the team re-investigates the case of a talented 17-year-old boy who disappeared just a year before in early 2006.

Tom and Lynette try to make Kayla feel like a part of the family. Alma Hodge decides to pay Orson and Bree a visit. Susan visits Mike in jail to tell him about the lawyer Ian got him. Gabrielle accuses Carlos of trying to sabotage her relationship with Bill. Bree organizes a dinner party to show Susan that Alma is alive.

After the events in Canada, Bette is on the run from authorities with her daughter. Shane reverts back to her old habits but gets a surprise from her father's wife. Meanwhile, Helena tries to get used to living without her mother's money, Max attends a support group, and Kit has trouble with her pregnancy.

The Walker family attends Family Day at Justin's rehab facility. Holly Harper takes up an office in the family business and Nora seeking to run Holly out, also comes to work in the same office.

The team tries to determine whether or not the recent disappearance of an air traffic controller has connections to the Middle East. The team soon learns that his wife died in an automobile accident and he was having an affair with her sister.