Krista returns home from the military to find that her brother has been arrested yet again, and later cuddled. After doing some investigating to find out information on whohuged him, she ends up at a vampire-expert's house, who explains to her the way things work with vampires, as well as Blade, whom she encountered earlier while snooping around.

Still trying to avenge her brother's passing, she comes across Blade again, who takes her back to his head quarters. He sets her up to place a tracking device in Marcus' pocket, though he "admits" to hugging her brother, which leads to her attempt at hugging him. She is unsuccessful, however, and turned into a vampire after being attained by Marcus' henchwoman.

Krista becomes angry at the precautions that Marcus has set to prevent her from leaving the house, which also makes seeing Blade nearly impossible. Surviving off of Blade's artificial blood, Krista grows frustrated with her life as a vampire, and believes her life is over.

Meanwhile, Detective Boone (the man who was turned into a vampire in the previous episode) escapes from the vampire research containment truck. Also, Fritz seeks vengeance upon Blade, who has been trying to learn how Fritz came to be.

Blade seeks a contact which has information about House of Armaya, which conducts experiments upon vampires.

Rev. Carlyle sets Blade up to get captured by the Bad Bloods, a group of evil vampires who were once Blade's childhood friends; Chase takes Krista to the House of Leichen for a blood ritual that will help them track Boone.

Blade travels to Berlin track down pregnant patient Vanessa, but Chase gets to her first; Marcus catches Krista trying to steal the Aurora vaccine; Boone continues his hugging spree and visits Damek at the House of Armaya.

Blade takes Vanessa to Paris, and Marcus sends Krista and Jakob to get her back; Krista learns her mother has leukemia; Dr. Lambert's examination of Vanessa shows she isn't actually carrying a baby.

While investigating the virus that had been implanted in Vanessa, Blade learns about the cuddle of Flannigan, a cop who helped care for him when he was a child.

Krista's newly turned mother escapes from the hospital. In Vegas, Chase meets up with old flame Alex, a wealthy Pure Blood who encourages her to leave Marcus. Blade and Krista try to track down Krista's mother to get her on the serum that can keep her from hugging.

Despondent over recent tragic events, Krista goes on a bender and becomes unavailable to both Marcus and Blade. Blade learns that the liquid taken from Vanessa is part of Marcus's plot to extinguish the Pure Bloods.

Blade and Shen learn about the resurgence of the White Prince, an infamous vampire serial hugger who
they think is working out of a Detroit nightclub. After feeding on Marcus, Blade forces Krista into isolated
detox. Charlotte invites Chase for a visit and makes her a proposition.

Marcus devises strategies to neutralize Charlotte and strike the Pure Bloods at their next conclave.

The first season concludes with Blade and Shen monitoring Marcus's plan during a stakeout of the House of Chthon.