In this special double-bill, marking Casualty's 20th anniversary, action takes place both in Holby and Cambodia, where Duffy has set up a clinic.
Charlie, Guppy, Abs and Comfort head to Cambodia to help out Duffy. When a young boy asks for help with his sick father, it sparks a chain of events that put Guppy's surgical skills to the test and prompt Charlie to raise suspicions about the clinic's surgeon, Mike.

Meanwhile, back in England, Maggie and Harry are learning to work with a new doctor on exchange from Cambodia. When a young man is brought in, suffering from an overdose, a call from Cambodia forces Harry to make a decision that will have fatal consequences.

As tensions run high in Holby, things take a turn for the worse when a bus full of schoolchildren crashes and topples over.

The ward is in chaos in the wake of the school bus accident and tensions are running high between Harry and the new doctor, Somnang.
Meanwhile, even under traumatic circumstances, Kelsey is determined to play Cupid when she spots an opportunity between the bus driver and a friendly neighbour.

Over in Cambodia, Abs and Comfort help with a difficult birth, and Charlie's suspicions are confirmed when he phones Sam to check up on Mike's background. Duffy is upset that he went behind her back, but things with Mike are not entirely what they seem.

After all becomes clear, Charlie reveals his feelings for Maggie to Duffy - unaware that, back in Holby, Maggie's relationship with Somnang has taken an unexpected direction.

Nathan is continuing to worry about his future and becomes distressed when he cuts himself. Selena convinces him to take a blood test and he is glad to have her on his side, but what will his results say?
Harry turns detective when a woman is brought in following a suspected overdose. Events lead him to suspect her GP of acting inappropriately.

Meanwhile,Ellen is on a mission to convert the others to her health kick. An aggravated Kelsey decides a practical joke is the best way to get back at her, but her actions end up having unexpected consequences for Alice.

New paramedics Dixie and Cyd arrive this week and Josh is unimpressed by their laid-back attitude. When Dixie criticises Josh's management, he decides to break the two of them up.

Selena and Nathan are back together, but she wants to keep it from her colleagues. Nathan tries to undermine Harry by offering him a position which he would share with Selena. This plan backfires when it brings the friends closer together, which makes Nathan jealous.
Meanwhile, a new no-smoking policy on hospital premises for staff puts Kelsey in a bad mood. She cheers up when Alice has an idea for a staff game. Elsewhere, the rota for the paramedics has been changed behind Josh's back so that Dixie and Cyd are back in a team together. Josh is unimpressed by the effort to undermine him and partners Cyd with himself. Over the course of the day the relationship between Dixie and Josh improves, and this gives Cyd and Greg a chance to talk as well.

When a woman and her baby are brought into the emergency department, the subject of child abuse is raised, leading to a tragic revelation involving the baby's older brother.

Two men from the Health Authority are visiting the hospital today and Nathan is feeling the pressure. It is a chaotic day and the team is keen to impress.
Maggie walks in on Selena and Nathan kissing. Selena tries to explain but Maggie is angry and thinks that Nathan is favouring Selena because of their relationship. The atmosphere between the pair is tense and when they treat a patient together it doesn't help the situation. Meanwhile, Comfort gets dressed up for her date with Sean, but doesn't realise that he is taking her on a picnic. Things get off to an awkward start but the pair soon share a passionate kiss.

Two men from the Health Authority are visiting the hospital today and Nathan is feeling the pressure, as the drama continues. It is a chaotic day and the team is keen to impress.

Josh is due to attend an awards ceremony to mark his 20 years of service. But when a string of events makes him question society's values, his decision whether or not to collect his much-deserved award hangs in the balance.
Meanwhile, Comfort is blissfully happy after spending the night with Sean but her joy is short-lived when she overhears a private phone call. Elsewhere, Guppy attempts to impress Cyd but ends up pretending that it is his birthday as an excuse to ask her to the pub, and Kelsey suggests that Alice should try to make Guppy jealous to get his attention.

Selena decides to carry out a major accident exercise in a bid to prove that Holby is better than St James's ED, thus preventing the department's closure. But when she rubs people up the wrong way, her plan results in chaos.

Sean calls an ambulance when he discovers a lorry full of illegal immigrants. Comfort and Josh respond to the call. When Sean hurts his hand whilst helping and needs to go to hospital, Josh sees this as a perfect opportunity for Sean and Comfort to patch things up. Comfort realises she has made a huge mistake and rushes to catch him before he leaves.

Ellen has a brainwave to draw the public's attention to the closure of Holby ED, as the hospital drama continues.

She ropes in Kelsey and Alice and they all jump into the City's water fountain in white t-shirts, causing a media frenzy. They are interviewed by a local reporter (played by Radio 1 DJ Scott Mills).

However, the stunt results in an unexpected consequence for Ellen...

Meanwhile, Harry decides to express an interest in the position at St James. With the Trust insisting that if he accepts the job he mustn't resist the closure of Holby ED, he has to decide where his loyalties lie.

Elsewhere, Josh is hard on himself when he makes a mistake with a patient.

A homeless woman called Jackie (Quirke) is admitted to the ED. However, she walks out, despite being told that she has gangrene in her foot and will lose it if she leaves. Jackie returns to the streets and goes to an internet café when, suddenly, a car crashes into it at high speed. Jackie and a young man are trapped in the rubble and Maggie, Charlie and Josh are faced with an agonising decision - whether to amputate Jackie's leg at the scene or risk both patients dying.

Selena is due to appear on television to speak to the Holby MP. Nathan tells her to ask the MP why the current Emergency Department should remain open when they could have a bigger, better ED at St James's. However, his plan is foiled when Selena is quarantined when a patient called Martin - played by guest star Joe McGann - is admitted to the hospital with radiation burns and Harry takes her place on the show

Holby MP Steven attends the opening of the new leisure centre where he becomes involved in a tussle with an angry constituent and accidentally falls down the stairs. Steven is rushed to A&E, where he is treated by Harry, but his condition worsens and he dies.

It's Christmas Eve and tensions are running high on the busiest day of the year at Holby.

Josh is found badly injured in the back of an ambulance. The outcome looks bleak and, although the team battle to save him, his life is left hanging in the balance.

As the staff try to come to terms with the aftermath of Josh's actions, an accident involving a vanload of prisoners and a crowd of residents protesting against a brothel ensures the staff have their hands full.

Prostitutes and punters make a desperate bid to escape as fire rages at the brothel. While staff at the hospital are alerted to the incident, Guppy provides back-up at the scene and treats an injured man inside the burning building following Maggie's instructions over the phone.

The gang decide to get away from all the recent tragedy, but their seaside trip goes horribly wrong. Nathan's mother causes havoc for her son, with unexpected results for Selena.

Harry acts on Maggie's advice that he needs to be more personable if he wants to succeed in his election campaign when he comforts a distressed Alice - but Nathan sees an opportunity he can't resist. Meanwhile, he waits impatiently for Selena's answer to his proposal.

Harry is suspended by Nathan, after he persuades Alice to make a formal complaint. Abs has an emotional day. Kelsey is forced into taking desperate measures, leading to a nasty surprise

Greg tells Cyd how much he wants the duty officer job - Josh's job. But he has a bitter pill to swallow when Dixie walks in and announces that she has been offered it.
Meanwhile, Nathan tells Kelsey that he won't tell anyone she is moonlighting as a prostitute if she keeps quiet about his visit to the brothel. Selena later praises him for making a tough call by suspending Harry for sexual harassment.

Elsewhere, Sam finds Alice crying in the staffroom. She tells him that everyone hates her because she is the one who made the complaint about Harry.

Kelsey agonises over whether to tell Selena the truth about Nathan as their wedding approaches.

Can Harry win enough votes at the election to save his department from closure? A young woman's real identity causes trouble in the ED.

Alice has made a big sign for reception, announcing the saving of the department, as the popular hospital drama continues.

Jeff and Dixie cope with a difficult drunk in a fight on the street, and Jeff proves his prowess as a paramedic.

Meanwhile, Harry and Selena deal with a pensioner brought in by Jeff, but they fail to save his life and Harry is distraught.

Later, Nathan decides he needs to apologise to Harry. He goes up to his office and, through the blinds, sees Selena and Harry in a passionate embrace.

Posh new nurse, Nadia, works her first shift and triggers a war with Kelsey. Selena feels Harry's absence and Nathan puts the mockers on her new love prospect. A trio of mountaineers attempt to keep a dark secret.

Dixie is jealous that Cyd is spending so much time with Greg.
Meanwhile, new Army consultant Lt Col Andrea Petersen arrives and quickly riles Selena by being rude to an overweight patient having a heart attack. Later, Andrea tells Dixie that she's keen to do a shift with the paramedics.

Elsewhere, Nadia persuades Guppy to give a patient a suppository for her. Andrea is angry when she finds him carrying out a nurse's procedure and Kelsey is made to do it instead.

Kelsey takes it upon herself to tell the whole department about Cyd catching Greg and Andrea in the ambulance together. Embarrased about the whole situation, Greg tells Andrea that they should keep quiet about their relationship.

Jeff and Dixie arrive at a farm where the farmer has discovered an unexploded WWII bomb. They head into the field to find three badly injured children and realise they need a doctor - leaving Cyd and Greg to bring Andrea to the scene.

A reporter who was taking photos in a nearby churchyard when the bomb went off is admitted to the hospital and asks Kelsey to persuade Nathan to let him report on the aftermath of the bomb.

But when Derek realises that the reporter plans to ditch Kelsey for Nadia, he encourages Kelsey to find a way of getting Nadia out of the picture...

Sam, Alice, Guppy, Kelsey and other staff members attempt various fundraising schemes for Comic Relief, much to Nathan's annoyance and he bans any further fundraising. Angus Deayton is at the hospital to have a splinter removed from his finger.

Sam blackmails him into helping them with an auction for Comic Relief. Nathan then changes his mind after speaking to a former nurse at the hospital and supports the staff's attempts to raise money

Greg is still trying to get back together with Cyd but she is unimpressed.

Elsewhere, Nadia shows off her Kylie concert tickets and Kelsey is desperate to go. However, Nadia invites Abs instead. He says he's too busy working, so she determines to get his shift changed.

Mystery man Stitch turns up at a casino where Nathan is losing a lot of money and drinking heavily. When Stitch spots a croupier at the blackjack table running a 'top-hatting' scam with a shifty looking man he drags her outside and orders her to end the scam.
Later, the croupier meets the shady character in the underground car park, and just as Stitch goes into the car park to check on her, the man slashes her across the face. Stitch spots Nathan close by and demands his help.
Nathan is impressed with Stitches handiwork and learns that he's a consultant.
At the hospital, tension mounts when Stitch tries to take over as Selena tends to the croupier.
He pressures Selena and Guppy to treat what he thinks is a tracheal bronchial injury but Selena thinks it's something else. And when the power fails Selena is unable to prove that she's right.
That night, Stitch tells Selena he's looking forward to working with her - as he leaves the hospital with a sexy nurse...

Maverick new consultant Stitch makes a dramatic impact on ED, but not everyone is impressed.

Sam's eyes are opened on a paramedic shift when he dashes to the aid of two ladies in distress.

On an evening in a bar, Stitch treats everyone to a drink and encourages Guppy to get on and do his surgery training.

Meanwhile, Cyd and Greg are acting all lovey-dovey, much to Dixie's annoyance, and Nadia is surprised to realise that Stitch is playing footsie with her under the table.

Stitch ignores Nadia after their night of passion, but they are forced to work together when two war veterans, Tom and Reg, arrive in the emergency department. When Stitch invites Nadia up to the office for a bit of fun, Nadia can't resist.

When Tom learns that his old friend Reg doesn't have long to live, he feels obliged to honour his friend's wish - to let him die with dignity. Nadia leaves Tom alone with Reg as she heads up to Stitch's office.
Tess arrives in Resus to find that Tom has tampered with Reg's life-support equipment and leaves Guppy in charge while she goes for help. Tess bursts in to Stitch's office - and as they leave for Resus, Nadia crawls out from under the desk.

When the medics fail to save Reg, Tess demands to know where Nadia was and she confesses that she was with Stitch in his office - but he denies they were together.

Meanwhile, Dixie struggles with her feelings for Cyd, when Cyd asks for time off to go camping with Greg. And Selena discovers she's pregnant - but is the baby Harry's or Nathan's?

Dixie's feelings for Cyd are becoming more obvious, especially to Jeff.

Meanwhile, Maggie is still trying to persuade Selena that she must face her situation head on and, elsewhere, Charlie worries that Stitch is a bad influence on Guppy

Josh is forced to go back to medicine when there is a medical emergency on a plane with a suspected terrorist.

Elsewhere, Selena tells Nathan she is pregnant and they come to a decision.

Meanwhile, Tess and Abs's odd behaviour is noticed by Sam.

After being pressured by Nathan to abort their baby, Selena tends to young mum Coleen who's at the hospital after slipping on a toy at home. When Coleen's sons Stan and Archie start misbehaving, Nathan is forced to look after them. Later, Nathan tells Selena that maybe they should have a baby. Will Selena decide to keep it after all?
When Sam fails to turn up for work and Alice admits to Tess that she told him that Tess and Abs were an item, Tess angrily informs Alice that this could seriously affect Sam's bi-polar condition. When Greg and Alice find Sam's flat empty but his medication left behind, a frantic Tess flees the hospital to find him. A man named Steve ends up at the hospital after crashing his car in a rage over his daughter Lucy's boyfriend Matt. When Matt arrives at the hospital with mild injuries, Tess stitches him up and sends him on his way. But when he's rushed back in with a brain injury and dies, Steve makes a shock revelation

Tess is terrified about Sam's wellbeing - he's been missing for a week with no sign. She enlists Abs's help and, together, they scour the city for him.

Meanwhile, Alice has also been worried about Sam's disappearance, so much so that Kelsey begins to work out her true feelings for him.

Elsewhere, at the site of an accident, Greg makes the heroic decision to enter a pit full of junk and save a trapped boy. However, in doing so, he defies Dixie's orders and puts himself in immense danger.

Nathan is determined to stop Selena from aborting the child she is carrying. Dixie learns the decision about the transfer.

Stich is forced to try and save a man's life after an accident occurs at the hospital. Josh suffers with flashbacks following a nasty knife attack.

Something happens which forces Nadia to remember past events from her own life. Nathan and Selena clash at Tess' party.

Selena is upset when an abandoned baby is found as it reminds her of the pregnancy that she terminated recently. Stich attempts to make Guppy more worldly.

When Stich continues to push Guppy things get out of control for him.

When Cyd is bitten by a poisonous snake she finds her life in danger. A secret is revealed by Dixie. A tired Guppy makes a mistake.

People start to turn on Stitch. Arguing neighbours clash on Bastille Day.

Guppy makes a massive mistake. Josh attempts to keep Dixie and Greg away from one another.

A tragedy occurs in resus after Guppy and Stitch argue. Harry hears a shocking secret from Selena.

Stitch takes the blame for Guppy after he makes yet another major mistake. Selena decides to be honest with Harry about she really feels about him.