In the first episode of the season things get crazy for Christina Hawthorne after having to move to James River Hospital because something happened at Richmond Trinity. Christina has to get along with new bosses this go round. Romance is in the air for Christina and Tom as well as new job positions.

Marcus wants to date Camille but isn't sure how it will go because she is the boss's daughter.

Christina deals with a bad car accident and has to find out what caused the grandmother to drive erratically, also candy returns from Afghanistan earlier than expected.

Christina has difficulty getting the only doctor at James River hospital to perform the surgery and on prisoner whohuged a pastor. The doctor doesn't want do the surgery and because of his religious beliefs. Tom hopes to get some good about his elbow soon.

Christina tries to prepare one mother for a total loss of her daughter at any time. Her daughter is in desperate need of a kidney transplant and has trouble finding matches because she is of mixed race. A little boy hoping for a meeting from his hero thanks to the make a wish foundation gets disappointed when a celebrity he is not familiar with decides to do a favor for his hero and she felt that the hospital and try to give the little boy a happy moment.

A woman from the Afghanistan who may have suffered a series fall while pregnant may have trouble getting treatment because of the language barrier. Tom finely undergoes surgery for his elbow. Christina catches her daughter at her home with an employee from the hospital.

Christina's friend Donna comes into the ER to be checked out. They discover she has encephalitis that she contracted from the person who raped her because of that her insurance won't treat her because of the disease she contracted.

Isabel goes too desperate measures to keep her son safe from Foster here after becoming concerned for his health. Christina and detective Nick Renta are desperate to find Isabelle and the real reason she kidnapped her son and disappeared Tom and has to go back into surgery and repair his elbow.

In the wake of a critical situation involving her daughter, Christina turns to Det. Nick Renata (Marc Anthony) for help. Elsewhere, Kelly searches for a mourning mother's camera; Erin and Christina butt heads over Tom's career; and Steve is haunted by a past figure. Sara Gilbert guest stars.

James River Hospital is about be inspected to see if it can stay open as a running hospital and not be forced to close down. Just as the inspection is about to get started a construction accident has everyone going into a panic mode.