Christina and Tom's wedding doesn't go as planned, Nick investigates the cause of an attack at the hospital. Candy finally goes into labor after almost losing her life.
Tom and Christina deal with the explosion at the hospital and her pregnancy differently. Camille may have found a new love interest. Bobby and Christina argue over hospital duties. Also a little girl is left at the front of the hospital for no apparent reason.
Nick asks Christine and for help with his mom who is ill, Dr. Steve shaw gets a surprise visit from his father. An internal affairs investigator comes to James river looking into the events surrounding the attack that recently took place. Tom is becoming concerned with Camille's interest in the new doctor at the hospital practicing under Tom.
Jimmy Dupree is still questioning the nursing staff of James River about the events that led up to the attack and nick is questioned about the attack that night. James River holds a health affair that leads Kelly to get in an argument with bobby over how to continue after a capital MERSA outbreak is suspected.
Christina and Tom spend the day with some speciaal kids visiting the hospital. And bobby is interviewed about James River for an article that. Kelly and Dr. Marshall may find they have something in common as they get to know each other better.
Christina and Nick thorough his mom a party Camille discovers something about my Miles that could change their relationship drastically. Bobby holds a fundraiser for the James River cancer and research lab; also problems become a problem for the CEO of James River Hospital
Christina is given an opportunity after losing her job at the hospital. Camille and miles have to make a decision about their relationship after learning something about Miles. Bobbie makes a mistake that could cost her the job and Christina once held. Tom's dislike of Nick only increases.
After Christina discovers that life has become too stressful she decides to seek help in the form of therapy. Christina talks among a lot of things from her husband to her childhood. Tom has to keep his friend from thinking that negative thoughts while dealing with an unexpected diagnosis.
Christina's daughter tries to help her mom through changes her decision will have on those she cares about most, Camille will have to tell Miles goodbye after hearing that he has decided to leave the hospital.
Christina returns to the hospital and Tom must perform surgery on a friend. Elsewhere, Kelly experiences a game-changing moment; Bobbie and Steve contemplate an all-important change; Camille mulls over leaving for college.