When Spider-Man and Max Modell experiment on a sample of Venom symbiote, it escapes and unleashes a weapon of unknown purpose.

When Toddler Groot lands on Earth to deliver an urgent warning, Spider-Man must decode the message and keep him out of the evil clutches of both A.I.M. and Baron Mordo.

In the midst of a symbiote attack on New York, Spider-Man must convince Marc Spector, a survivalist who has recently given up his secret hero identity as Moon Knight, to help him defend the city.

After Aleksei is turned back into the rampaging Rhino by Swarm, the Spider Team must battle for their lives in the Underground Monster League contest.

Spider-Man discovers Norman Osborn is responsible for the Venom Symbiote's escape; Norman, aka the Dark Goblin, brings the Generations team to battle against Spider-Man.

When Spider-Man and his allies attempt to track down the missing and dangerous Lizard, they discover that Venom has returned to seek revenge on the earth.