Peter Parker struggles to balance the best summer vacation ever and his responsibilities as Spider-Man.

Spider-Man is excited to start his second year as a superhero and as a student at Horizon High but discovers that Doc Ock also claims to want a second chance. Can Otto be trusted?.

Spider-man's popularity nose dives, thanks to Pete's pictures in the Daily Bugle. Spidey battles a female 'Doc Ock' as the real plan of Dr Octopus is revealed.

Spider-Man tangles with the Wakeriders, a thrill seeking group using Vulture technology.

Spidey teams up with Ms Marvel to investigate a strange school.

Pete becomes weary of supplying footage to Jameson that is used to trash Spider-man's reputation. In a bid to scoop Pete, Eddie Brock tries to photograph substance V-252 and Venom is born.

Venom goes after Peter Parker's family and friends and threatens to expose his secret identity.

A Mystery Villain puts a bounty on Spider-Man's head, bringing on attacks from Panda-Mania, Hippo and Overdrive.

Anya must step-up and embrace being the Spider-Girl; Spider-Man is lured into the Mysterious funhouse and learns that there is a bounty on his head.

Spider-Man faces off against his most bizarre bad guy yet, Jack O' Lantern. Then he turns Prowler, a reluctant villain, to the side of heroes when he helps him save his brother.

Spidey tracks the identity of the mysterious boss that put a price on his head and who has been sending villains after him.

Spider-Man and Miles Morales discover Doc Ock, whose mind has been hiding inside the metal body of The Living Brain, has been behind the mysterious bounty for Spider-Man's head.

Spider-Man must fight his way through the Super-Villain Holding Facility to challenge The Living Brain, the robot body that is housing the mind of Doctor Octopus.

The Bloodgem accidentally reawakens Gwen Stacy's dormant spider-powers, turning her into Ghost Spider!.

Doc Ock, now in Spider-Man's body, intends to bring New York City to its knees, but instead finds his newly acquired brain still contains some of Peter Parker's memories.

Doc Ock must adjust to his new life as a hero and is tested by rising crime boss Sand Girl.

Superior Spider-Man is confronted by the Avengers, who suspect that he is not who he claims to be.

When a new criminal duo, Cloak and Dagger, emerge at Midtown High with the plan to take revenge against Midtown's benefactor Tiberius Stone and his company Alchemax, Superior Spider-Man must take them down and protect the school.

Superior Spider-Man must face his most challenging opponent yet when Venom escapes from stasis and attacks Midtown High.

When a series of attacks by a suspected team of super-villains captures The Avengers, Spider-Man is left to figure out who could be behind it.

Spider-Man takes his mission to The Cellar where he believes The Regent is using the powers of Cloak and Dagger, as well as other supervillains, to hold The Avengers captive.

Spider-Man has to take down the slick new villain Slyde, who is stealing various chemicals from around the city in an effort to create a deadly virus that could wipe out New York.

Spider-Man teams up with Spider-Girl, Ghost-Spider and Doc Ock to track down a new threat - the mysterious Goblin Nation.

Spider-Man and Harry Osborn seek the Goblin King to determine who is behind the Goblin Mask.

In order for Spider-Man to defeat the Goblin King, he must first bring together Doc Ock, Spider-Girl, Ghost-Spider, Miles Morales and Harry Osborn.

The assembled Spider Team (Spider-Man, Miles, Ghost-Spider, Hobgoblin, Spider-Girl, and Doctor Octopus) must stop the Goblin King, now armed with a Goblin Mech Suit, before he destroys New York.