Impressed with B.O.B'.s indestructibleness, Coverton decides to clone a piece of him. After too many clones, B.O.B. alarmingly begins to diminish little by little.
Inspired by DreamWorks Animation's 2009 blockbuster feature film, this new series follows the further adventures of the beloved monsters- B.O.B., the gelatinous blob without a brain; Link, the prehistoric fish-man; Dr. Cockroach, the half-man/half-insect mad scientist; and Susan (aka Ginormica), the incredible growing woman-as they learn to adapt to a new world filled with bizarre aliens.