London 1891. As the police investigate a series of gruesome cuddles, renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives know there's something darker at play. In search of someone close to them who has been lost, they recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them on their journey.

Vanessa and Sir Malcolm attend a party at the home of Egyptologist Sir Ferdinand Lyle and meet Dorian Gray. The party takes an ominous turn when medium Madame Kali hosts a séance. Meanwhile, Ethan befriends Brona Croft, a young Irish immigrant.

Victor confronts his firstborn creation, while Vanessa receives a vision from Mina calling for help. Meanwhile, Ethan returns to the fold when he discovers that he needs the money to pay for medicine for Brona.

Ethan and Brona take in the Grand Guignol, and the American meets Dorian for the first time. Meanwhile, the Master invades Malcolm's home to reclaim Fenton, and Malcolm realizes who their nemesis really wants.

Vanessa relates the tale of how she and Mina Murphy became close friends... and how she ultimately betrayed her friend to the fiend that now holds Mina enthralled.

Vanessa's latest vision leads Sir Malcolm, Ethan and Sembene to explore a plague ship in search of Mina. Meanwhile, Van Helsing reveals to Dr. Frankenstein more details about the creature that has taken Mina. Later, Vanessa's night with Dorian unlocks something dark within her.

Malcolm and the others must deal with the aftermath of Vanessa's night of passion with Dorian, when she is possessed by the demon that haunts them... and who has ties to the Master who controls Mina.

While Malcolm makes his final preparations to save his daughter Mina, Vanessa says her goodbyes to Dorian and Caliban says goodbye to the man who took him in. Meanwhile, two men come hunting for Pinkerton and Victor receives an unexpected visitor.