Vanessa Ives is barraged by an onslaught of disturbing occult images brought on by the mysterious Evelyn Poole. Because of the massacre he committed in the Mariner's Inn, Ethan Chandler decides to leave London. Under pressure from The Creature, Dr. Frankenstein works to bring Brona back to life. After Mina's funeral, Sir Malcolm returns to London to discover that a whole new evil is hunting Vanessa.

Haunted by the witches, Vanessa seeks solace from Sir Malcolm. Scotland Yard Inspector Rusk searches for the sole survivor of the Mariner's Inn Massacre. Evelyn Poole enchants Sir Malcolm. Dr. Frankenstein gives the re-born Brona a new identity. The Creature gets a new job. Dorian Gray meets an intriguing woman with a secret. Ferdinand Lyle reveals the disturbing backstory of the Verbis Diablo. Evelyn's daughter, Hecate, hunts down a prize for her mother.

In a flashback, Vanessa meets The Cut-Wife, who teaches her how to harness her powers. Isolated at her lonely cottage on the moors, The Cut-Wife quickly realizes the extent of Vanessa's powers and warns her of the danger that lies ahead and the evil that pursues her.

Lyle reveals that the Verbis Diablo relics tell a very dark and disturbing story that affects Vanessa; Rusk interviews the survivor of the attack at the Mariner's Inn; Hecate tries to get closer to Ethan; Angelique and Dorian's romance grows. Back at Sir Malcolm's mansion, Vanessa, Ethan, Sir Malcolm, Sembene and Lyle carry on their evening as something evil lurks within, ready to strike.

After sealing the townhouse against further intrusion, the group goes its separate ways for the moment. Rusk starts asking questions of Ethan, Brona and Victor draw closer, Vanessa teaches Caliban how to dance, and Evelyn launches her next steps in her campaign to seduce Malcolm.

Vanessa and Ethan give Sir Malcolm tragic news; Lavinia Putney is disturbed by an encounter with the Creature; Roper hunts down Ethan; Dorian hosts a lavish ball in Angelique's honor; a glorious night turns to horror for Vanessa.

Not feeling safe in London, Vanessa and Ethan flee to the Cut-Wife's cottage on the lonely moors. While there, Vanessa and Ethan settle into a domestic life as they draw closer together until a figure from her dark past resurfaces. Meanwhile back in London, Lyle and Frankenstein uncover even more disturbing information from the Verbis Diablo relics. We soon discover that Lily isn't what she appears to be.

The Creature unleashes his rage on Frankenstein over Lily. Inspector Rusk discovers Sir Malcolm's connection to Ethan Chandler. Malcolm goes to confront Evelyn but quickly finds himself assaulted by another one of her deadly enchantments.

Back in London, Vanessa and Ethan learn that Sir Malcolm is in danger. Desperate to save him, Vanessa goes alone to battle Evelyn. Ethan heads out to Evelyn's mansion with Frankenstein, Sembene and Lyle. Lily reveals her true self to Dorian.

While Malcolm and Victor face the ghosts of their pasts, Lucifer shows Vanessa her greatest desire and offers to make it real if she will take her place at his side.