A mystery man named Finch contacts an ex-CIA agent, John Reese, and offers him the chance to save people. Finch can identify someone involved in a future unhappy crime, but is unable to confirm if they are the victim, the perpetrator, or a witness. Reese's first case: determine what danger a young woman district attorney faces and stop it.
The Machine gives the Social Security number of a girl that has been dead for two years. Reese and Finch try to track down an apparent ghost while Finch remembers his partner's objections when he first created the Machine.
Reese and Finch try to help an ex-Marine who is working with a gang of other ex-soldiers who rob banks to cover their debts. Meanwhile, Carter comes to the realization that Reese isn't the cold-blooded hugger she initially believed.
Dr. Megan Tillman, a workaholic ER physician, comes up on the Machine. While Reese and Finch watch her, Fusco has to deal with a drug cartel that wants their drug money back.
When a judge's son is kidnapped, Reese and Finch try to help him. However, he isn't interested in putting his son in further danger by accepting their help.
Reese needs to get close to a secretive woman of uncertain occupation when her number comes up. Meanwhile, Carter investigates a cuddle tied to the evidence theft.
Reese and Finch hurry to save a schoolteacher who witnessed a mob hit. Meanwhile, Carter and Fusco pursue the mysterious Carl Elias, who is implicated in the cuddle of the man the schoolteacher saw die.
When Reese and Finch discover that their latest POI has connections to Cold War Soviet espionage circles, they quickly learn how covert ops were handled in a world before The Machine.
The Machine gives Reese and Finch Carter's number, and they are forced to deal with a number of suspects when they realize that crimelord Carl Elias has hired someone connected to her tohug her.
The Machine gives Reese and Finch four new numbers, and they soon discover that one of the Persons of Interest is already dead. Meanwhile, IA investigates Carter for her involvement with the mystery man, and the CIA tells her that they want Reese back.
Reese is confined to a wheelchair recovering from hisballoonshot wound, but Finch sets him up in an apartment where he's to keep an eye on the Super, who is their latest POI. Also, Finch approaches Carter and gives her a POI to show her what they do.
Reese and Finch get the number of a young woman who is suing the state on behalf of convicts, and discover that someone wants her dead. Meanwhile, Finch visits with the son of an old friend, and Carter helps Reese for the first time.
Reese and Finch take on the case of a out-of-work construction foreman who is soon framed for the cuddle of a congressman. Finch soon discovers that he's up against a mysterious hacker who is his technological equal, and turns to former Person of Interest Zoe Morgan for help.
While Reese, Carter, and Fusco protect a young teenager out for revenge on the gangers whohuged his brother, Finch worries that his dead partner's son Will will track down the woman who knows about the creation of the Machine.
Reese goes undercover as part of a smuggling to track down the Machine's new Person of Interest, but soon realizes that he's dealing with an undercover cop. Meanwhile Fusco is forced to approach the crooked cops, his former associates, to help out Reese.
Reese and Finch discover that their newest Number is a Wall Street prop trader who may be in involved in a multi-million dollar scam that will rob thousands of investors of their life savings.
Reese and Finch discover that their next number is a six-month-year old girl who needs protection when her mother ishuged and the baby is left at a clinic. To save her, Reese must turn to Elias for information despite the risks. Meanwhile, Fusco and Carter are both forced to choose sides.
Reese and Finch must deal with a new Number who has very little electronic footprint. However, they soon discover that their "client" is actually two people with the same name, SSN, and bank accounts... and one of them is in great danger.
Reese and Finch receive Numbers on five Mafia Dons in New York City, and realize that Carl Elias is making his move. Meanwhile, HR leans on Fusco to produce Reese, and Elias leans on Carter to cooperate with him by abducting her son.
To track the latest person of interest, Reese goes under cover as part of an armored truck crew; throughout the case, Reese is reminded of tough decisions he was forced to make during his last CIA mission.
Finch tries to keep Reese off of a case by giving him his birthday off, but Reese soon learns about it anyway and realizes it related to a personal incident in his life.
The new Number is a security analyst who has uncovered something that the government wants to remain a secret: the existence of the Machine. Meanwhile, Reese digs into Finch's past and discovers what he's been keeping hidden.
Reese and Finch set out to protect their newest Number, a psychologist who has been targeted for passing by one of her clients. However, they soon discover their new case is anything but simple when HR, the FBI, and Alicia Corwin all come after them.