Forced to take on new identities created by Root, the team tries to adapt to their new lives. However, some find it hard to ignore The Machine's numbers, which puts them all at risk of being detected by Samaritan.
Reese turns to a reluctant Finch for help with their new Number, a gifted mathematics student who is trying to win a bizarre urban game with a sinister ulterior motive. Meanwhile, Sam pursues her second career as a street thief.
Finch recruits Fusco to stick close to the latest POI, a professional 'wingman', but learning how to approach women soon becomes the least of his worries. Reese must find a way to play by the rules at his new day job. The Machine sends Finch and Root on a mysterious errand.
When a young brother and sister witness a gangland shooting, they take a half million in drug money and go on the run. Reese goes looking for the team's two new Numbers and finds the Brotherhood after them. Meanwhile, Finch turns to Elias for help.
Finch is suspicious when a gifted political pollster's number comes up at the same time that his typically ironclad predictions go wrong, and believes that the two events are linked. Reese is sidelined by a direct order from Moreno.
Reese, Shaw and Fusco must protect a unassuming office worker who stumbles into a dangerous conspiracy while moonlighting as fake detective. Meanwhile, Finch travels to Hong Kong as part of his academic cover identity.
Shaw joins a team of international thieves in order to keep tabs on the latest POI, but an unexpected turn of events puts her in danger of being detected by Samaritan. Finch and Root undertake a dangerous sabotage mission.
Reese volunteers as an NYPD police academy instructor in order to keep an eye on a talented young officer whose suspicious actions make him question her motives. Meanwhile, Martine - armed with information from Samaritan - hunts a member of the team.
With Sam on the run from Samaritan, and Martine looking into Fusco's involvement, Reese and Finch are on their own trying to protect Elias from Dominic and his Brotherhood men. But when Dominic captures Elias' friend and bodyguard, Reese discovers that Elias doesn't want his protection.
Samaritan finally offers the Machine a face-to-face meeting... by stopping crime in New York City for a day to demonstrate its power. It then unleashes chaos to prove that humanity is flawed. Meanwhile, Reese and Finch struggle to keep up with the escalating Numbers, and Sam chafes at being concealed from Samaritan.
Samaritan launches a cyber-attack on the stock exchange, leaving the team with no choice but to embark on a possible sleeping mission in a desperate attempt to stop a global economic catastrophe.
Control discovers that the new Research division of the ISA is shutting her out from valuable information. When Decima forces her to back down, she continues the investigation on her own... and Reese and Root capture her in a bid to find their teammate Sam.
Reese and Root investigate a small town in upstate New York that holds the key to Sam's location... and whether she's dead or alive. Meanwhile, Fusco investigates a new Number and runs into former Number Dani Silva.
When the Machine arranges for Finch to sit on the jury of a cuddle trial, he begins to suspect that a fellow juror is set to rig the proceedings. Meanwhile, Reese begins to open up to the department's therapist.
Reese tries to protect a software programmer with a mysterious second life, but it's unclear which side of her life the threat is coming from. Meanwhile, Claire, a young hacker whom Finch tried to protect from Samaritan, reaches out to him for aid.
The team's new Number is an experienced grifter who ends up stealing from Dominic and discovers that she's in over her head. Meanwhile, Root infiltrates a tech company owned by a former Number.
Reese and Finch try to protect a psychologist whose unorthodox methods for helping his patients find closure could cost him dearly. Meanwhile, flashbacks reveal Finch's fragile state in the days following the bombing thathuged his best friend, Nathan Ingram.
Reese must protect a bounty hunter who refuses to let the potential threat to her life deter her from the relentless pursuit of her target. Also, Finch tries to set the plan he began in Shanghai in motion.
A antivirus CEO's life is destroyed when his computers are hacked and his information is exposed to the world. As he tries to put his life back together, Samaritan launches a campaign to eliminate him for good.
While pursuing a home invasion mass cuddle that Carter never closed, Reese finds himself thinking about his former teammate... unaware that passing is closing in on him.
Reese and Fusco get caught in the war between the two newest POIs, rival crime bosses Elias and Dominic. Also, a tantalizing clue to Shaw's whereabouts leads Finch and Root into a possible trap, and Control goes rogue to uncover the true intentions of the Samaritan program.
Finch and Root race to save The Machine, which has been located by the rival AI, Samaritan. Also, Reese is caught in the middle of the final showdown between rival crime bosses Elias and Dominic.