The enigmatic Dr. Helen Magnus recruits insightful forensic psychiatrist Will Zimmerman to join her in the quest to track, study and protect the strange and often terrifying creatures that secretly populate our world.

As Will attempts to help Alexi coup with his abnormality, Helen gets a visitor from her past.

Dr. Helen Magnus and the team are still recuperating from the Cabal attacks that devastatingly took down so many Sanctuaries around the world.

Magnus and Druitt struggle to come to terms with the apparent passing of their only daughter, Ashley. Druitt seeks revenge on her captor, the Cabal. Magnus, however, clings to the faint hope that Ashley could somehow still be alive. While Druitt leaves to exact his bloody revenge, Magnus takes a quiet, methodical approach to prove that Ashley is alive.

Meanwhile, Will, Henry, and Bigfoot take on the daunting task of organizing and processing the hundreds of Abnormals who survived the worldwide attacks, but now seek refuge at their Sanctuary.

Kate, not quite ready to give up her life as a petty thief and swindler, makes a bold move to cash in on a rare Abnormal species that has been delivered to the Sanctuary. With a quick phone call, she's worked up a deal, certain to catch a hefty sum. But as she prepares to capture her "windfall," the Abnormal escapes, sending her, along with an unimpressed Henry, on an adventurous hunt through the city for the runaway.

With all the chaos around them, the Sanctuary team must come to terms with how to rebuild after the Cabal's attacks.

A superhero is trapped by Mangus, and his lack of finesse affects the team's work. Elsewhere, Will and Declan go on the search for a creature that's loose in the city, after the discovery of an eggshell.

A confused Dr. Magnus finds the Sanctuary and surrounding city has been destroyed, but she has no idea how it happened. While searching the remains she is pounced on by a vicious creature, leading to two armed men rescuing her and taking her to a nearby abandoned building. After being hosed down and dumped in a room on her own Magnus becomes fearful when an aggressive man, with a familiar face, enters.

Henry tries to determine why a seemingly docile domesticated abnormal suddenly turned unhappy after it attacks a research scientist.

Will tries to defend Magnus from the heads of the Sanctuary Network when they accuse her of committing a shocking cuddle.

While carrying an abnormal, Will and Magnus' helicopter crashes on a decommissioned oil rig.

Helen reunites with Jimmy who transports an elemental Abnormal to the Sanctuary. However they are tracked down by the underground Mobsters. Kate proves her loyalty and bonds with Jimmy over a common history they share.

Magnus and Will investigate the disappearances of teenagers with links to them spending time at a rehab clinic in Mexico. Magnus and Will are shocked to see Nikola Tesla as the program director. Tesla reveals the treatment he has been using on the teens for their addictions. Tesla eventually his true motive of turning his patients into Vampires.

Magnus and her team rescue the passengers of a sinking ship off the coast of South Africa. Back at the Sanctuary, one of the passengers is found cuddled and Druitt becomes the prime suspect.

Magnus, Will and Kate travel to Mumbai, India, on their mission to investigation the link to a cuddle. To make matters worse Will becomes ill before he mysteriously disappears.

Will begins to experience strange visions that are connected to the Cult of Kali. Magnus has difficulty with finding the solution to their problems.