While searching for Charlie, Alex finds a caterer who was caught in the crossfire; Grace's mother asks for a priest; Dana consults with Cassie about a male stripper.

Alex and Charlie are confused about their relationship; Alex and Maggie disagree about a car crash survivor; Dana is forced to treat an injured motorcyclist; Zach bothers Maggie about dating.

It's a not-so-Happy Birthday for Alex, who's still reeling from her split with Charlie. To make matters worse, she makes a promise to a young girl, whose own birthday is derailed by her father's sickle cell crisis. Charlie treats a paranormal skeptic, only to discover this supernatural naysayer has a haunting of his own. And Cassie confronts her inner fear of parasites with some exposure therapy, as she treats a brother/sister duo riddled with every infestation.

Tempers flare as Dev's med school rival, Billy Scott arrives at Hope Zion, while Alex breaks the rules and puts her job in jeopardy to help Manny save the life of an at-risk youth, and Charlie and Maggie treat an 1812 War re-enactor, whose complications align with the historical character he's playing.

Although Alex's patient is desperate for a liver-transplant, the only donor is an estranged father that's hiding in witness protection, forcing Alex to go to new depths to make sure both survive. Hope Zion's CEO Thomas Leffering cuts costs by banning expensive surgeries, butting heads with a defiant Dawn. Sensing his E.R. might be next to go, Zach plans for a perfect day only to be faced with the 10 plagues of Egypt.

Alex's alarm at home goes off; Alex and Maggie ask Charlie for his opinion on a patient's treatment; Zach is persuaded by a patient while transitioning the ER to an urgent care facility.

Alex and Maggie deal with a tough lawyer after surgical complications with their cancer study patient; with the E.R. now an urgent care facility, Zach and his team aren't equipped to handle an accident victim.

Charlie and Manny treat a couple; Maggie evaluates the interns; Billy asks Maggie to be his mentor; Dawn tries to get her Chief of Surgery position back.

The doctors rally together to try to save an unknown man who was struck by a subway train; Charlie realizes who the John Doe is.

Alex tries to distract herself from her grief; Charlie and Shahir try to track down Alex's brother.

While Charlie tries to save a young man's life, he is haunted by a mischievous spirit.

Alex and Maggie work together to deliver a baby; Charlie treats a magician.

Alex tries to help patient who hurt himself breaking into a house; a friend of Dr. Dev Sekara has been beaten by the police; a heart patient wishes to open an animal sanctuary.

Alex is challenged about the value of holistic medicine; Charlie's abilities are questioned; two filmmakers go to Hope Zion Hospital.

The board questions the hospital staff about Charlie's behaviour; a patient convinces Alex to use new-age techniques; Shahir agrees to do an in-utero surgery.

Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.

Alex and Charlie put their wedding plans aside; Zach takes a special interest in a case; a coma patient who wakes up with no memory.

Following a mass casualty accident involving a bus full of teenagers, Alex & Charlie rush to the scene to try and save the kids while waiting for backup to arrive. The Hope Zion Hospital family must band together to overcome the tragedy and move on to the next chapter of their lives.