After being cuddled in the heart, Dr. Alex Reid has a profound experience in the liminal space, while a desperate Charlie Harris and his ex - Dawn Bell race against the clock to save her life. Meanwhile, Dr. Joel Goran is pulled in to the ER to treat a suicidal patient that tests his duty as a doctor, and Maggie Lin makes a bold decision that changes her relationship with Gavin Murphy.
With her body still in a coma, spirit form Alex shares an emotional journey with Charlie in the spirit world as he ?ghost-doctors' a brain-dead mother-to-be. Meanwhile, Joel forms a tight bond with a lively drug addict while trying to treat his necrotic leg. Hope Zion Hospital also welcomes its new OB/GYN, Dr. Sydney Katz, who throws Maggie off her game.
A crisis at the hospital jogs Alex's memory; a building collapse forces Joel and Charlie to work together; the doctors try to give Maggie some advice.
Alex returns to work for the first time since her stabbing. She is introduced to her buddy colleague, as she returns. Joel ends up involved in a deadly situation at a local street clinic. Gavin shares a euphoric experience, with someone unlikely.
A car accident brings a 'she-bear' mother and her son to the hospital. Alex Reid and Joel Goran discover the mother is in need of a transplant - and her son is very adamant that he be involved in the surgery.
Dawn Bell instructs them on procedure and, before they know it, the trio are brought before an ethics panel - including one very unconvinced psychiatrist. Meanwhile, the mother's spirit is determined to get Charlie Harris to do her bidding, which includes stepping out of his comfort zone when console her son.
Then, Charlie finds himself pulled into the ER to help Zach Miller with a patient whose obsession might cost him his life. Plus, new resident Rian and Maggie Lin search the hospital for Hope Zion's very first "code crown", which results in having to answer to a shaken Dawn.
Alex, Joel and Maggie face a mysterious case. Charlie has a unexpected link with a patient. Zach questions his abilities as a father.
Shahir and Alex try and save a woman's memory, who is suffering from Alzheimer's with surgery. But another doctor requires life-saving surgery. Tom has to make a decision when he discovers a secret. Charlie is embroiled in Dawn's plan.
Alex and Charlie perform a double surgery on a teenage girl; Joel works at the clinic; Maggie must pull through when she is reunited with the Zarb family.
Alex and Joel are challenged with a marathon surgery. Charlie has a day off that's full of surprises. Dana, Zach and James are tested.
Celebrated neurosurgeon Thor MacLeod gives Alex an offer; Charlie deals with a fatigued spirit.
Charlie tries to treat two female MMA fighters; a fight between Dana and Molly ends up in the hospital; Dawn must save a woman's heart.
Two patients need the same heart; a patient has never-before-seen orthopaedic hardware; Dr. Maggie Lin feels the pressure of the upcoming boards.
Alex encounter a trapped teenager during a hike in the woods; a woman refuses to see anyone but Joel; an exotic dancer comes to the ER.
Alex and Maggie perform an intricate procedure; Joel thinks his dad is hiding something; Charlie suspects foul-play when he sees a boy and his grandmother.
Alex asks for help in diagnosing a teacher with a mysterious illness; Charlie must explain his actions; Dawn must make a big decision.
Alex and Charlie try to save the life of a man on the run; a spirit won't leave Alex alone; Maggie and Zach try to help a couple; Joel and Shahir help a bride walk down the aisle.
Alex and Dana try to save a single mother's life; a hockey player's mobility is at stake; Charlie gets advice on winning back Alex; Sydney comes clean.
At an off-site army base, Joel and Zach get in a precarious situation; a hypothermia victim fights for the life; Alex, Maggie and Rian write their Surgical Boards.