Physics genius Quinn Mallory has been tooling around in his basement for months, trying to create an anti-gravity device. However, he has stumbled on to something much greater - something that appears to be a gateway! Curious as to what's on the other side, he invites his old friend Wade Wells and his physics teacher, Professor Maximillian Arturo, to venture into the gateway with him. While creating the gateway, however, Quinn uses too much power, and the vortex snags a fourth passenger: Rembrandt Brown, a former pop star who just happened to be in the neighborhood. The vortex drops them in a world where a new Ice Age has begun, a world where they must somehow survive until Quinn's timer reaches zero!.

After barely escaping the last world, the Sliders think they are home. But to their horror, Quinn and Arturo learn they are not and have instead arrived on a world where the Soviet Union rules America. Rembrandt has been arrested for trying to use American money and the only way to save him is for the others to help a group of revolutionaries rescue their imprisoned leader.

The Sliders arrive on a world where disease is running rampant, and it appears that Quinn's counterpart is the source of the nastiest of these epidemics, a plague called the "Q Virus". Quinn is quickly tracked down and captured by the health agency, but the Sliders' problems escalate when Wade develops signs of being infected. Now Arturo is in a race against time to develop a cure.

The Sliders arrive on a world that will be destroyed by an asteroid before they are due to slide. Arturo works with Bennish to develop an atom bomb to destroy the asteroid and Rembrandt gets caught up in an end of the world celebration, while Quinn and Wade confront their feelings for one another.

The Sliders arrive in the British States of America, where Arturo's double is plotting to assassinate a prince and take the throne. When the Sliders inadvertently foil the plot, they come into contact with a group of rebels trying to bring freedom to America.

When the Sliders are forced to depart from a world early, the timer is damaged and the group becomes separated. They arrive on a world where the "Free Love" movement of the 60's is still alive, and the Hippies are protesting the American troops in Australia. While Wade and Rembrandt fall into the company of a commune who mistake them for extraterrestrial prophets, Quinn and Arturo try to repair the broken timer.

The Sliders arrive on a world where brains are admired over brawn, and Quinn and Arturo are treated as celebrities! Quinn discovers that his counterpart is a popular college athlete and must take part in a championship game, while Arturo's counterpart is married to Arturo's late wife. Arturo's joy at learning this is marred when he discovers that his counterpart is about to undergo divorce proceedings.

The Sliders arrive on a world where roles are reversed with women holding the positions of power. Arturo becomes a candidate for the mayoral race in San Francisco, trying to bring about a "men's rights" movement.

The Sliders arrive on Rembrandt's idea of paradise: a world where his double has achieved all the fame he's ever wanted. They discover that his double has been dead for eight years, but Rembrandt gets swept up in a major comeback concert. Unfortunately for him, an old enemy plots to get rid of him once and for all.

The Sliders arrive on a world where there's no pollution, crime, poverty, or overpopulation, and get a rare chance to kick back and relax. Their luck seems to be running solid, because Wade wins the lottery shortly after their arrival. However, Quinn soon discovers the sinister purpose behind this lottery.