The Sliders arrive in an airplane, which begins to crash land. However, they learn that it is just a simulation and the beginning of deadly game show in which the losers die.

On a world quickly running out of natural resources, Rembrandt meets his number one fan but finds her to be a little to friendly. Meanwhile, Quinn and the others meet Logan, a scientist at Prototronics that's trying to develop sliding. However, they learn her plans for sliding are far from noble.

The Sliders arrive on a world where electric tornadoes have almost completely wiped out the population. They find a secluded village somehow protected from the tornadoes and a dictator that may prevent the team from ever sliding again.

The Sliders arrive on a world just like their own, only time is moving at a rate of twelve years slower than normal. There, Quinn encounters his young double and tries to change an upcoming event in his life, despite the other Sliders' warnings.

On a world where a group of social misfits have learned to torture people by entering their dreams, Wade becomes a target of the group's leader.

The Sliders land on a world with little water and come to the aid of a mysterious young woman whose gift to find water is being exploited by a group of thugs.

On a world of magic and dragons, Quinn is mistaken for a wizard and kidnapped by an evil warlock bent on immortality. Meanwhile, Wade tries to help Rembrandt's love troubles with a love potion, but it backfires and makes Rembrandt fall in love with her.

After barely escaping a world engulfed in flames, the Sliders now find themselves in a Los Angeles dependent on the sale and production of oil. Unfortunately, they learn they've brought along a piece of the fire from the last world and that it has a mind of it's own.

The Sliders arrive on a world in which the United States is a monarchy, and Rembrandt is Duke of Hemmingshire. When Rembrandt sees Danielle, a woman he recognizes and who in actuality is the Duchess of this world, apparently about to give birth, he goes to help. However, what he doesn't know is that the husbands give birth on this world.

On a world where the legal system is in the form of televised game shows, Quinn is arrested, tried and sentenced to passing for the crimes of his double.

The Sliders land on a world where the human race was wiped out by robots. Quinn and Rembrandt are captured by the robot's demented creator and are going to be used in a mind-transfer experiment.

On a world where people are enticed by consumerism and giant malls in the sky, the Sliders get jobs as mall employees to find the mother of an abandoned child. Arturo is a reluctant Santa, Rembrandt and Wade his elves while Quinn gets an administrative job. Meanwhile, Wade faces some strong emotions when she meets her sister and father.

The Sliders arrive on a world where the government forces everyone to work at maximum efficiency, and sends "fractures" who break from the stress to theme parks where they are brainwashed into role-playing fictional characters. When a grumpy Arturo is diagnosed as a fracture, he is sent to one such park and brainwashed to play a 19th century detective on the trail of Jack the Ripper.

On a world ruled by Egyptian culture, Quinn is used in a life-after-passing experiment and thought dead. The others miss the slide when trying to save a woman from a sacrifice and become trapped in a pyramid with a big scarab.

The Sliders arrive in a small community that is distrustful of outsiders. When they hook up with a geologist looking for her missing assistant, they stumble upon the town's sinister secret.

The Sliders arrive on an Earth threatened by lethal radiation Pulsars that are slowly eating away at Earth, the only chance the population has for survival is to make use of the Sliding technology developed by their military. With Quinn and Arturo's help, preparations begin for an evacuation, but a more chilling mystery begins to unfold when a large body count of coma victims begins piling up.

Quinn and Maggie return to her world with Earth Prime's coordinates stored in Jensen's timer. As Wade makes the final list for those who can slide to safety, Arturo races to modify the new timer to slide more people. Unfortunately for them, an unexpected danger lurks the base and one Slider will not make it to the next world.

The Sliders arrive on a world where civilization has fallen to a bacteria that creates flesh-eating zombies. Shortly after arriving, Quinn is bitten, and starts turning into a zombie as well!.

A creature embeds a parasite in Maggie just before the slide, which takes the Sliders to a world where young adults are used in a mandatory organ-donor program. The others will have to find Maggie before she finds the perfect mate and lays her eggs.

Wade and Rembrandt recall a particularly harrowing adventure on a world at the mercy of catastrophic earthquakes. When Wade falls beneath the earth, Quinn embarks on a risky rescue mission while Rembrandt and Arturo fall into the company of the less-than-friendly natives.

The Sliders track Rickman to a superstitious town. Their search is further complicated when Quinn and Maggie are captured by natives living in a mysterious fog. There, Quinn runs into someone from his past â- himself.

Quinn and Rembrandt head down to Mexico to blow off a little steam. Getting back into the United States turns out to be a bit of a problem when they get mixed up in an illegal snake trade and find themselves stuck in the middle of a jungle, surrounded by deadly snakes and the tobacco cartel. Meanwhile, Wade and Maggie run into problems of their own while they search for the other Sliders.

The Sliders arrive back at the New World they helped Rickman colonise, shortly after the Colonel arrives himself. While the Sliders try to figure out how to stop Rickman, they discover this parallel world's unusual inhabitants: dinosaurs, including a particularly aggressive Tyrannosaurus Rex.

Wade becomes infatuated with Stoker, a rock band whose members are secretly vampires. Meanwhile, the other Sliders try to find clues to Rickman's whereabouts before he escapes them again.

The Sliders splash down near an island inhabited by humans cross-bred with animals, the results of painful experimentation's by the local scientist. When the timer is taken by a now feral and partially transformed Colonel Rickman,Quinn must bargain with the scientist to escape, but Rembrandt's infatuation with a cross-breed slave puts the alliance at risk.