A bus full of kids crashes and sends the team racing. Bash's life is upended when he is reunited with a woman from his past. With Dr. Bishop still unconscious after his stroke, Mags struggles to find support in her mentor's absence. Theo faces repercussions from his family after taking a full-time job away from home, and June has an important career decision to make.

Rania's arrival triggers unwanted memories for Bash; Mags can't win her new boss' approval.

A morbidity and mortality review forces Bash and Dr. Bishop into conflict.

As Dr. Bishop faces challenges returning to work, Bash's loyalty is tested; Mags has a harrowing encounter with an aggressive patient.

Bash helps his undocumented friend Khaled apply for asylum. At the hospital, he treats a couple from India reconciling with their desire to return home. Theo and his charismatic medical student Jake treat a teenage boy with an eating disorder. Mags gets an unexpected career opportunity but faces self-doubt after her recent setbacks. Dr. Bishop and Claire adjust to new hurdles in their relationship.

Rania and Bash make a difficult decision. Theo is surprised by his unresolved anger while treating a young boy who accidentally ate his parents' cannabis edibles. June's brother Charles brings urgent news about their father. Mags decides to broaden her horizons while advocating for a member of the hospital cleaning crew who was injured on the job. Dr. Bishop faces a daunting professional challenge.

When treating a young woman with a rapidly progressing health crisis, and an overbearing doctor/father, Bash and Mags have a difference in opinion. Dr. Bishop confides in Bash about a professional dilemma. Theo over-invests in the rocky relationship between his new-parent patients. June puts herself on the line for a sick woman following a gastric bypass, against the advice of a powerful surgeon. Mags makes a big career decision.

Bash's past weighs heavily on him as he fights for an emancipated teenager with a failing kidney. Mags treats a baby with a complicated heart condition. Theo is thrown by an asthma patient's brazen mother. After a patient makes waves, Dr. Bishop advises Bash to play it safe, while championing a new initiative in the York Memorial emergency department. June backs Dr. Bishop's proposal for a Trauma OR, sets boundaries with her brother and tries to get a surgical patient to his wedding.

Fighting to save a baby with a heart defect, Mags is flooded by memories of her own health struggles as a child. With his performance still being closely scrutinized, Bash remotely treats a cluster of patients with an undiagnosed illness in Aleppo, while also caring for the victims of a Toronto apartment fire. Dr. Bishop asks Claire for a life-altering favour. Theo's unpredictable decisions start piling up, and June's professional and personal lives collide.

Bash draws on his war zone experience when extreme weather causes the hospital to lose power.

Mags is surprised when a patient triggers her. Bash treats a woman suffering from Locked-in Syndrome, and the husband whose life revolves around caring for her. Bash takes Amira out of town for a joyful dance recital, where a familiar face surprises them. Dr. Bishop's ambitions for the department lead to consequential staffing changes. June and Dr. Singh's differences get in the way of their work. Theo treats a teen with a rare presentation of ADHD and gets a visit from his father.

Bash's career is threatened, leaving him with a major decision to make. When a toxic father needs a liver transplant, Bash deals with the man's estranged son. While treating a woman having strange reactions to a spider bite, Mags employs a strategy to work alongside Novak. Theo helps a young lupus patient make her dreams come true, and takes steps to rebuild his life. June discovers her father's secret. Dr. Bishop and Claire begin a new chapter.

As Bash fights for Dr. Bishop's legacy, big questions about his own future are finally answered.