Bash's decisions lead to conflict with the new Chief of Emergency Medicine, Dr. Neeta Devi. Mags struggles to save a patient who thinks the system gave up on her. June has trouble with her new roommate, who happens to be her almost-step-sister, and gets a work proposal from Novak. Theo has trouble adapting.

Bash treats a man with a rare medical condition. Mags gets a visit from her parents and goes above and beyond for a pregnant woman with an undiagnosed condition. A misunderstanding with a rabies patient lands Theo in trouble. June and Novak negotiate a tentative working relationship. Devi starts to make changes.

Bash treats a woman whose ketamine therapy went awry. Mags loses confidence in her new boss. June realizes she has too much on her plate. Theo reunites with a young former patient whose life may depend on the passing of another patient.

Bash struggles to balance a dual residency in surgery and emergency and finds himself at odds with his direct supervisor June, while they treat a couple of skydivers with a unique relationship. Mags speaks out against her supervising doctor, putting her on shaky ground morally and medically. A mistake comes back to bite Theo.

Recovering from a personal crisis, Mags worries about how to get her life back on track. Bash takes an unorthodox approach to treating a soldier with PTSD. Theo treats a terminally ill child whose father is desperate for a drug trial. Devi's changes to hospital policy have repercussions on the nursing staff. June lets her emotions get in the way of her job.

Bash and Amira have an argument over her future. Bash treats a diabetic woman who is overly dependent on her 18-year-old son, whose shocking health crisis requires all of Bash's expertise. Mags questions herself as she adjusts to very limited parameters. June has a difficult experience with a patient. Claire and Devi reach a breaking point.

Bash reels from Amira's bold decision; tensions flare at an after-work dinner party; Devi struggles to keep her staff in line as turmoil erupts over her leadership; Mags treats a highly sensitive person; Theo considers breaking some hospital rules.

Bash's life is scrutinized during his citizenship interview; when treating survivors of a building fire, Theo needs Bash's help with a scared young boy; Mags helps a recovering addict who swallowed her keys; June and Bash treat estranged brothers.

Bash's psychiatrist suggests an unexpected form of therapy. Mags gets evicted and meets an old patient who holds a grudge. Theo makes some questionable choices with a patient's mother. June's personal and professional worlds collide.

Bash tries saving a couple whose wedding was waylaid byballoonfire; Mags' demanding teen patient needs birth control; June struggles with an old habit; an activist patient puts Theo in his place.

A software glitch takes down the emergency department; Bash explores new terrain; Mags searches for a new cardiologist; June is fed up with her bosses; Theo attempts a stable dating life.

Bash faces an important figure from his past and must solve a public health crisis; hospital administration calls Devi's leadership into question; Mags doubts all of her choices; June is asked to oversee a sensitive procedure.

Bash has a major realization; Mags faces an overwhelming health crisis; Devi stands behind her choices; June confronts loss; Theo witnesses a devastating event.