A group of mythic Greek gods called The Titans escape after being entombed for centuries, and proceed to systematically eliminate The Elders. Phobe and Paige are nearly killed by the all-powerful deities, but are saved by a mysterious Whitelighter named Chris. A conflicted Leo is formed to transform The Charmed Ones into Goddesses if they're to have any hope of prevailing.

The Charmed Ones now find themselves as super-powered Goddesses, but must stay focused on vanquishing the Titans before their own powers corrupt their minds. Meanwhile, Leo answers the call to become an Elder, shattering Piper's happy family life, and sending her into a rage spiral. Also, Chris is appointed as the sisters' new Whitelighter.

At the Springfield Aquarium, Marge accompanies the kids on a school field trip. Lisa spots penguins flying and after Bart has shown off his "flawless pearls," which results in him being taken the hospital, where a lack of insurance card keeps him prisoner. Homer has the insurance card, but is nowhere to be found. As a solution, Homer gets a mobile phone and a few extra unnecessary accessories, which only leads to him not paying attention to where he is driving. That is until it is much too late and he drives off of a pier. Judge Harm takes his license away and Homer is no longer able to drive. Marge picks up the slack and starts becoming "Stresserella." Homer walks to Moe's, but much to Moe's dismay he decide to keep on walking and starts getting healthy. Homer walks to work and is the only employee to arrive, everyone else is caught in a traffic jam. Marge is frazzled from all her driving, meanwhile Homer sings and walks about the virtues of walking when he is stuck by a car; the driver of the car was Marge. Marge, who cares so much for Homer, tries to help in his recovery, but Homer perceives that she might be trying to kill him. It leads to fight, which in turn leads them to see a marriage counselor. After Marge leaves, the counselor suggests that Homer perform one unselfish act of love to win Marge back, in other words take her to dinner. Homer decides to one up that suggestion and invites everyone in Springfield (except the Flanders family) to a backyard barbeque in Marge's honor. Homer joins Jackson Browne in a duet to sing his praises of Marge.

The Sole Survivor in the Amazon is crowned as the reality series wraps up its sixth edition. The Final Four players are whittled down to two and the seven-person jury votes for the winner. "It's a toss-up when we get to the Final Two", says host Jeff Probst. "It's not a sure thing". The big change in the finale, says Probst, is that the concluding vote takes place immediately following the last Immunity Challenge. "There's no time to think about it", he says.

After Peggy organizes a bird society, Bill begins trying to attract birds by laying out food in everyone's yard. When pigeons begin to flock to Bill's yard as well as all the neighbors, Dale is called in to exterminate but can't get rid of them. Dale calls in the "pigeon god," Arlen's greatest exterminator, Sheila Repkin, who turns out to be a beautiful woman who takes an interest in Dale. When Sheila invites Dale to go on an all-night exterminating session with her, Nancy fears that Dale may cheat on her the way she used to cheat on him. Meanwhile, Luanne celebrates her 21st birthday by going to a bar with two friends, and brings Hank along as the designated driver.

Goren and Eames enter the closed world of a thieving Irish Traveller clan when they investigate the death of a Ann Lawson, a probation officer who was run over three times after meeting a friend at the bar. They soon learn that Ann, a probation officer, had been involved with Malcolm Bryce, the father of Paul, one of her charges. It appears as though Ann is also very close with the thieving Irish Travellers they are investigating, determined to save a young girl from their style of life.

Still no word from Lisa.
After eighteen hours, dozens of voicemail messages and the filing of a missing person report, Nate still doesn' know where his wife is. And his desperation is growing at an exponential rate. The morning following Lisa' disappearance, Nate phones David and tells him, "I'm starting to freak".
Nate' not the only who is afraid for his wife. After the dance class incident, Federico takes Vanessa to a psychiatrist who is shocked to learn the number of medications she' been taking. When Vanessa says that she feels like she' in a hole that keeps getting deeper, the doctor' assessment is blunt: "It probably is". Complicating matters is Vanessa' sister, Angelica, whose idea of being helpful is to take Vanessa on lavish spending sprees and to criticize Federico at every opportunity.
Creating even more stress for Nate and Federico is the fact that Fisher & Diaz is suddenly inundated with business. In order to manage the huge workload, David and Federico violate some regulations, and nudge some mourners along in order to keep to their tight schedule. When Arthur questions these methods, David gives him some practical advice: "When we're in the weeds like we are today, Arthur, you just gotta move 'em in and move 'em out".
Similarly, Margaret Chenowith decides that it's time to move out what's left of Bern. She phones Brenda - who has moved into her own apartment - and requests that she join her and Billy to dispose of Bern's cremains. Brenda doesn't want to be around Billy, but her mother won't hear of it. The three of them meet in Margaret's condo, where the grieving widow empties Bern's urn over the balcony railing. "There", she announces, "Now he'll be in Brentwood for all eternity". She spends the rest of the day drinking and plaintively crooning Roberta Flack covers.
Back at the Fisher house, Ruth deals with her emotions in her usual fashion - by suppressing them. She has stalwartly maintained that Lisa will return unharmed, but eventually even Ruth gives in to despair. When George Sibley, a mourner at a recent funeral, comes to retrieve his glasses, Ruth breaks down in his arms. "I'm so sorry... I've just cried all over your jacket", Ruth tells him, "and you're a complete stranger". Sibley kindly replies, "Not anymore, I'm not".
Unlike her mother, Claire confronts her problems head on. She once again rebuffs Russell and in a meeting with Olivier, she lets him know exactly what she thinks of him: "When are you going to get over the fact you never became Picasso and now it's too fucking late- Afterward, she discovers she has another situation to resolve - a home pregnancy test that she takes comes up positive.
But what about Lisa? Nate does, finally get some news, but it provides no comfort: the police find her car in a state park. But Lisa is nowhere to be found.

The 16 players are reunited in New York City. Jeff Probst is the host.

J-ROC is caught in a compromising position by Ricky, Julian and Bubbles when they visit him regarding a local rap concert for the park.

At Woody's bar, Debbie emcees a charity strip contest during which one of the contestants goes too far and exposes himself to the crowd. A plainclothes policeman in the audience orders the patrons to leave, and the bar is closed. Debbie organizes a protest and publicly condemns Stockwell as a homophobe, putting her beau, Detective Horvath, in an awkward situation. Stockwell maintains that illegal activity at Woody's caused its closing and mentions Brian as proof that he is not a homophobe.

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