Homer gets into trouble with football gambling debts. As compensation, Fat Tony wants to use the Simpson home for shooting the adult film Lemony Lickit: A Series of Horny Events. Homer gets Marge and the kids to leave the house by sending them off to Santas Village. Marge and the kids return home to find the production is still underway. Marge, outraged by Homers latest bit of idiocy, leaves. Homer, home alone with the kids tries to figure out what to do next. Just when Marge is about ready to reconcile with Homer, she encounters Caleb Thorn, a good looking scientist with a passion for saving the endangered manatee. Homer and the kids go on a quest to find Marge and they stop and stay with some country cousins, meanwhile Marge is finding herself while helping to save manatees. Homer tries to win Marge back by save a herd of manatees from a gang of jet skiers. His effort pays off as Marge takes home the endangered species of her own, the endangered devoted husband. The family decides to take a mini-vacation and Homer gets a manatee sent to the power plant to fill in for his job for the next few days.

Stan finds Deputy Director Bullock, his supervisor, starting a relationship with Hayley. However, he can't risk saying or doing anything about it because he's up for a promotion at the CIA. Meanwhile, Steve finds Dick Cheney's BlackBerry and uses the contact numbers to play pranks on political figures from around the world.

Peter and Brians friendship becomes strained after Brian begins dating Megs high school teacher. Peter finds a replacement in new best friend James Woods, who is visiting Quahog because of a suggestion to rename James Woods High School after Martin Luther King Jr.

Julius Caesar is making his way towards Rome, though Lucius Vorenus is contemplating while the army has encountered so little resistance during their patrols. In Rome, Pompey begins ordering a retreat of his forces and he assigns his best men to take the entire city's treasury to their planned destination. Meanwhile, Atia plans on using foul play in order to force her daughter to stop loving a lower class citizen.

The Fugitive Task Force must deal with an escalating race war as they pursue a Mexican gangbanger and convicted murderer when he escapes from prison after killing a white supremacist.

When a devastating bomb explodes in central London, causing multiple deaths, a terrorist group with a hatred for human life claim responsibility. With their leader facing extradition, the bombers announce that crippling attacks will be launched at ten hour intervals until he is released. Will the team be able to track down the perpetrators before they strike again?