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After discovering that Mary (Jessica Biel, who does not appear in the episode) has filed for divorce and signed away custody of her son, Matt is at a loss for how he should to break the awful news to Eric and Annie. Simon informs his new girlfriend, Rose (guest-star Sarah Thompson), that he won't have sex with her, but avoids telling her the reason behind his decision. She gets fed up with him but comes back to him when she finds out his true intentions for them - marriage. Meanwhile, Ruthie's boyfriend, Vincent (guest-star Thomas Dekker), asks Martin to get Ruthie to break up with him. Also, Eric gets involved once again with the Davis family children when little boy Danny (guest-star Drake Johnston) is being adopted by Cecilia's parents, George and Gwen (guest-star Brad Maule and Holly Fulger), but forgets to mention that the kid is part of a package deal as Danny has three sisters in Social Services as well, and try to take them in as well. Kevin is about fed up with Lucy as he's frustrated that they haven't moved out of the Camden home as Lucy is stalling with the Realtor over a new home. Lastly, Lucy and Kevin may have finally found the perfect house.

Charlie brings the remaining bachelorettes home to meet his parents. Charlie must decide whom he will choose.

Jack finds that his efforts to bargain with Marwan for the location of the missile strike are futile. Heller pushes his son for information when CTU discovers that he may have had contact with Marwan before the attacks. Logan finds himself in the middle of a power struggle between Palmer and the ambitious Speaker of the House. Tony and Michelle explore their rekindled passion for each other, but their hopes for the future may be short-lived when a familiar player enters the game and takes a hostage.

Ephram prepares to leave for Europe as he feels that he has nothing left for him in Everwood. However, he's caught off-guard and questions his plans when Andy reveals the secret that Amy has been keeping from Ephram. Meanwhile, Nina and Jake contemplate going into business together, but the stress on their relationship proves a big obstacle to overcome. Meanwhile, Bright finally confesses he has feelings for Hannah.

Evelyn demands Jake spend a night at her place when she finds out he spent Spring Break with Judith's parents. Neither Alan nor Charlie are keen on the idea, but going to a bar after dropping off Jake quickly erases their concerns.

Charlie chooses his final pick, live on national television.

An axe murderer on death row is given a stay of execution just moments before it was to take place, on the grounds that there may have been tainted DNA analysis used at his trial. Now, without using any DNA evidence, the team must race against time and re-examine all of the physical evidence in the case, just as they get a call on a new double murder that looks suspiciously like the case they're working on.

Are new-age therapists just spouting psychobabble? Penn & Teller take on people who call themselves "Life Coaches". Are they really helping people or just offering their services for over inflated prices.

After the confrontation with Ichigo, Renji is left seriously injured and unable to fight. In a sort of "life-flashing-before-his-eyes" way, Renji reminisces his past in Rukongai, training as a Shinigami, but most importantly the factors that lead to Renji and Rukia's strange but somehow still close relationship. This sentimental episode features Renji and Rukia. (A little bit of Ichigo is thrown in to 'ground' the episode in the present.)

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