As the summer draws to a close in the Hamptons, Serena and Nate have everyone fooled into thinking they are a couple to cover up the fact that Nate has been hooking up with a married, older woman. Blair returns from abroad with a hot guy on her arm making a very jealous Chuck question his decision to leave Blair stranded at the heliport. Dan has spent the summer assisting a famous author. While interning for Eleanor Waldorf's company, Jenny sneaks an invite to a much-coveted Hamptons' White Party at which Eric introduces her to socialite Tinsley Mortimer.

Brenda and the squad investigate the murder of a hair stylist; Brenda's parents stop in for a visit on their way to Alaska; Brenda's father wants to know when she and Fritz are going to tie the knot.

In the sixth season premiere, Tree Hill residents make decisions that will change their lives forever. Lucas finally pursues his dream with the woman he loves, Brooke faces a reunion with her mother, Mouth makes a startling revelation, Nathan and Haley encounter a ghost from their past and the news of Dan's accident takes an unexpected turn.

Michael uncovers unbelievable news in Los Angeles when he seeks revenge against Whistler and Gretchen for Sara's death. Michael and Lincoln are reunited with the gang and receive an offer from a Homeland Security Agent they cannot refuse. Mahone suffers a devastating loss, and T-Bag is deserted during his flight to freedom.

Michael, Lincoln, Sara and the team work with Roland, a new team meber, to get a copy of the data card. Meanwhile, Wyatt continues his mission to track down the brothers while T-Bag makes his way north using the bird book as his guide.

In honor of Labor Day, Tony takes us backstage for a very special highlight show that includes goofs, silliness and some of the baddest food on the planet.

Whitney's love life starts to heat up while Lauren's starts to cool down. Meanwhile Heidi and Spencer fight.

When The Middleman and Wendy investigate a series of strange thefts, a supervillain named The Palindrome opens a portal that sucks Wendy to a bleak alternate universe, run by the ironfisted Fatboy Industries.

Public defender, Jerry Kellerman, defends a man that he is certain is innocent. Jerry struggles on the case while in front of a judge that despises him. Meanwhile in the DA's office, Michelle tries to right a wrong in a rape trial while the office doesn't want to be embarrassed by a wrong conviction.

An unemployed Dave struggles to regain his manhood and position in the family, landing himself in hospital.

After rescuing two children, Josh's rage spills onto their father, who may have attempted to kill them. The new inspector challenges Josh's position on the team.

Ric is offered the Director of Surgery job just before he attends his son's funeral. Jac attempts to mess up Faye and Joseph wedding plans.

While working as a charity street collector, Don meets an attractive girl who is nine years younger. He starts to hang out with her and her friends, but soon finds he isn't as young as he once was.