Mary coerces Matt into asking his friend Brian (guest-star Jason Behr) to take her out on a date despite his lack of interest in her. Although, things begin to heat up between the two kids while on the date - but ultimately ends in disaster after Mary finds out the truth. Meanwhile, Lucy is invited to a sleepover of popular girls, but Lucy is unaware of the group's real intentions for inviting her. Also, Simon begins to teach Ruthie how to swim without taking lessons. Lastly, Eric becomes convinced he's fat and thinks he's getting away with cheating on his diet.

After getting in a fight with the mysterious woman, Kendra, Buffy learns that her temporary death in the hands of the Master had activated the choice for the next Slayer, and she is fighting her. After calling a truce and convinced by Giles to work together, Buffy and Kendra team up to save Angel from Spike and Drusilla. Meanwhile, trapped in Buffy's basement, Xander and Cordelia start their relationship and Willow and her computer-mate, Oz start an intiguing friendship, until Oz is shot by another assassin who targets Buffy.

Doctor Bashir meets with a group of people who, like him, had their DNA altered to make them better. Unfortunately for these people, they suffered serious side-effects of the treatment and developed psychological illnesses that are difficult to reverse. Doctor Bashir attempts to find a solution to the problem.

Mitch receives a call that Caroline needs all available assistance during a rescue. Apparently a young girl named Rosanna is missing. Her mother Lucinda is real worried, but she doesn't speak any English, just Spanish. When Many finally arrives to the beach, he translates everything Lucinda says. When Manny asks Rosanna's younger sister Nikki what happened, she tells Manny that Rosanna was very sad and that she waited for the lifeguard on duty, Cody, to leave his tower. When Cody left to meet Lani at the movies, Rosanna went into the water, and Nikki never saw Rosanna coming out of the water.

Frank signs his new contract; Murphy is in the midst of negotiating her new deal. After Murphy can't make her appearance on the show, Corky fills in and does a great job conducting the scheduled interview. The network brass wants to give Corky the chance to report from the Middle East. The network only offers Murphy a one year deal instead of the usual three year deal and Murphy won't back down until the network meets her on her terms.