Games played include: Superheroes, Film, TV & Theater Styles, Newsflash, Duet, Party Quirks, and 90 Second Alphabet.

Winner: Wayne Brady.

Games played include: Weird Newscasters, Song Styles, Themed Restaurant, Narrate, Scenes from a Hat, and Hoedown.

Winner: Kathy Greenwood.

Piper contracts a deadly virus, and Prue and Phoebe cast an awakening spell in an attempt to save her life. Unfortunately, using magic for personal gain has consequences, leading to Piper's illness becoming an epidemic and the sisters no longer being able to sleep at all. Also, Prue quits her job at the auction house, and Phoebe enrolls in college.

When her sister Jill visits, Rachel worries about the sparks that seem to fly between her and Ross. Monica tries to seduce Chandler, despite having the flu.

Frasier goes on a date with a high school classmate who has a short temper.

Third year med student (and part-time OB nurse) Abby Lockhart begins her ER rotation. A flu bug sweeps through the ER. Carter tries to help a kid with muscular dystrophy while Cleo treats a kid who's been injecting hormones into himself. Corday discovers that her mother will be coming to town and then decides to pay her a visit. Lucy treats a dying homeless man. Benton and Romano clash over the treatment of a surgical case. Luka and Carol treat a young boy whose mother is injecting him with saline to get surgical procedures done.

Tonight, actor Jason Priestley.

Mario presents the quotation from the intermediary in Panama to Armando and Betty, who are suspicious. Armando is excited and asks Mario to travel to Panama without anyone knowing. Fredy takes it upon himself to meet the model for lunch.