When Sabrina realizes she has been turning down guys left and right since her breakup with Harvey, she casts a spell ensuring that she'll say "yes" every time she's asked out. Meanwhile, Hilda takes over ownership of the coffee house, but her people skills are scaring the customers away. Also, Miles develops a student-teacher crush on Zelda and Josh shocks Sabrina by taking Morgan out on a date.

Gil Grissom is the supervisor of the graveyard shift of Las Vegas' elite crime scene investigators. Holly Gribbs, fresh out of the academy, joins the team. Jim Brass is head of the unit and is trying to scare Gribbs from CSI. Catherine Willows, mother of a young daughter, is the number two CSI on this shift. Warrick Brown and Nick Stokes are competing to solve their 100th case to earn a promotion to CSI 3. Grissom investigates a murder staged to look like a suicide with precious little evidence. Warrick and Catherine take the case of a drunk who breaks into the house where he had been staying and is shot to death. Nick talks to a man who picked up a woman who drugged and robbed him.

Ash returns home, where he is pleasantly surprised by an old friend. Unfortunately he faces a new trial, as Team Rocket has besieged the famous Oak Laboratory and captured all the Pokéballs there.

An errand of Professor Oak's sets Ash on the road once again, but first he must face his old hometown rival, Gary, in a Pokémon battle.

The press have got wind that a nurse is HIV+ as the journalist involved gets checked in as a patient.