An extremely nervous Simon comes home to Glenoak to await the results of his STD test from the clinic. Eric counsels a woman (guest-star Erika Alexander) who is caring for her two daughters (guest-stars Bree' Anna Banks and Brandi Vanice) with sickle cell anemia and whose absentee father (guest-star Victor Love) is hoping to take them back with him to Memphis, Tennessee for treatment at St. Jude Children's Research Hospital. Meanwhile, Ruthie's ex-boyfriend Peter (guest-star Scotty Leavenworth) and his parents Paris and Vic (guest-star Bryan Callen) pay a surprise visit to the Camden family, which creates problems for Ruthie and her current boyfriend, Vincent (guest-star Thomas Dekker). A pregnant Paris (guest-star Shannon Kenny) and Vic decide to get married and ask Eric to be the minister to wed them. Also, Lucy and Kevin disagree over who should care for Savannah when Lucy returns to work. Lastly, Martin misses an important call from his father in Iraq while sneaking out of the house to be with his girlfriend. Martin begins to have second thoughts on their relationship.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.