Mike Delfino's bride will finally be revealed: will it be Katherine, or will it be Susan? Lynette faces the reality of another pregnancy, whereas Bree struggles to break free from Orson and her inhibitions. In the meantime, Gabrielle is put to the test by Carlos' teenaged niece, now in their care, and a new family with a dark past moves to Wisteria Lane.

As the citizens of Fairview try to make sense of a recent attack in their neighborhood, Lynette withholds a secret from Susan. Gabrielle gives niece Ana advice on how to get a guy's attention, whereas Bree worries how her affair with Karl will affect her friendship with Susan, and Angie is determined to protect her son and her family's past.

Tom and Lynette try to tell their kids that their mother is pregnant again, whereas Susan becomes convinced that Danny Bolen was responsible for strangling her daughter Julie. Bree considers whether she should go away for the weekend with her lover, and a chance encounter reunites the Solis family with Gabrielle's former lover, John Rowland.

Losing Mike takes its toll on Katherine. As Katherine unravels, Bree comes to her aid; Gaby grows weary of John's intentions towards Ana; with twins on the way, Lynette calls upon her family to step up around the house; Susan learns Julie has been harboring some secrets; and Angie throws a party for son, Danny.

When Juanita's party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she’s a responsible parent; Bree gets defensive when she's judged by a motel maid for having an affair with Karl; Lynette is put off by her new handyman when he defers to Tom for approval on all things; and Susan and Katherine come to blows over Mike.
Meanwhile, a lapse in judgment on Danny's part leads to a terrible mishap that Angie and Nick must cover up.

Bree begins to fall for Karl and drifts further from Orson; Katherine continues her sad attempts at seducing Mike, as her conflict with Susan grows; Gaby gets Juanita expelled from school; Lynette learns Tom is cheating on his mid-term, and Angie hides the truth about her mother.

Susan believes Katherine maybe have been Julie's assailant, but Lynette has her own suspicions regarding who may have strangled her. In the meantime, Gabrielle struggles to home school her daughter Juanita. The Bolens invite the Hodges over for dinner, and Angie confronts her husband about a secret he seems to be withholding from her.

Susan discovers a surprising connection between her husband and Katherine Mayfair, which leads her to question her relationship with Mike. Meanwhile, Gabrielle will stop at nothing to get her daughter Juanita in Catholic school, and Lynette's pregnancy becomes impossible to hide. As Bree tries to hide her infidelity, Angie uncovers the truth about Orson and Bree's less than perfect marriage.

In the wake of another unexpected attack, Angie decides the time has come for her and her family to move away from Wisteria Lane. In the meantime, Susan and Bree clash over the latter's affair with Karl Mayer, whereas Gabrielle and Lynette clash over the latter's pregnancy. Meanwhile, Katherine's crazy schemes have brought Mike to a point where he can no longer put up with her, and a heated argument between the two of them has shocking results.

Gabrielle and Lynette's friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny's vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.

After the terrible plane crash, the residents of Wisteria Lane reflect on what their lives might have been like if they had made different choices in life.

Susan turns up the heat for Mike while Bree learns that it won't be easy to take back the hurt she's caused Orson. Meanwhile, Lynette uncovers the true intentions Tom has, while Gaby is forced to examine the feelings she's suppressed about her heritage.

While Lynette balks at the idea of seeing a therapist for couples, Katherine visits her own psychiatrist. Meanwhile, Gaby and Susan decide to find out which of their kids are in the smartest group at school, while Angie is less than enthusiastic about Danny's new girlfriend.

Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.

Susan causes quite a stir when she invites a former stripper (guest star Julie Benz) into her home, because former exotic dancer Robin will have a profound effect on the ladies of Wisteria Lane: with three teenage boys at home, Lynette will need to keep a watchful eye on them; Bree needs to pick up a few tricks to engage Orson; Katherine needs to find a friendly companion; and Gabrielle needs help with her troublesome niece.

Celia comes down with the chicken pox, and having never had it herself, Gabrielle must keep her distance, so she stays with Bob and Lee for a while, and is suddenly reminded of what it feels like to be "single" again. In the meantime, Tom and Lynette forget little Penny's birthday, which leads the girl to go missing. Bree hires a promising new employee (guest star Sam Page) and Katherine makes a surprising discovery about herself. Meanwhile, Susan cheats on Mrs. McCluskey, whereas Angie grows concerned over Danny's disappearance.

Gabrielle and Angie head out to New York to track down Ana and Danny, and a chance encounter with supermodels Paulina Porizkova and Heidi Klum, Gaby's former co-workers, leads the former top model to an unexpected revelation about herself. In the meantime, Mike tries to prove to Susan that he is a man with a capital "M" after he feels emasculated by her, and the Scavo family is surprised to see Preston back from Europe... accompanied by a hot Russian gold digger. Bree discovers a surprising connection to her new employee and Katherine feels confused regarding her feelings towards Robin.

Angie's ex-boyfriend, Patrick, emerges after her trip to New York. Meanwhile it's game on between Gaby and Susan, as they go to shameless lengths to top each other's kids; Lynette believes there's more to Preston's fiance than she's letting on; Bree invites Sam over for a family dinner; and Katherine comes out of the closet.

Determined to derail son Preston's marriage to Irina, Lynette discovers the truth about her future daughter-in-law. In the meantime, Gabrielle offers to help out Bob and Lee in the most generous way, but does not consider the consequences. Bree begins to question whether Sam has a hidden agenda, and Susan gets creative to help Mike with his finances. Unbeknownst to Angie, Danny meets Patrick Logan for the very first time.

The Fairview strangler has been living among the women of Wisteria Lane. He once caught Gabrielle and Carlos in an intimate moment. Bree offered him a job and some dating advice. Susan encouraged his passion for art. Lynette will show him kindness and generosity. But... who is he?

This week it's the Women vs the Men as Gaby and Susan plan an elaborate scheme against their husbands; Angie comes face to face with her ex, Patrick Logan after years on the run; Lynette sees a different side of Eddie, and Bree has an encounter with a woman who knows Sam very well.

Angie discreetly relies on Gaby for help when Patrick threatens her sons life;Lynette comes to a shocking realization about Eddie;Bree offers Sam a generous payoff to walk away; and Susan and Mike's financial problems result in the ultimate sacrifice.

Bree considers revealing a secret, and Susan's financial problems worsen. In the meantime, Eddie gets in control of Lynette's fate, and Gabrielle puts herself at risk trying to help Angie.