Carlos's cuddle of his wife Gabrielle's evil stepfather and the cover-up by the housewives has far-reaching effects, as feelings of guilt begin to overcome everyone in different ways.
Susan discovers a dangerously thrilling way to help ease her guilt over being an accessory to the cuddle of her friend Gabrielle's evil stepfather, whereas Gaby herself plans a sexy surprise for Carlos to help him gain his sexual mojo back.
As Susan and Carlos bond over their feelings of guilt at the cuddle of Gabrielle's stepfather, Mike begins to think that the two are having an affair, and Bree suspects that her detective boyfriend, Chuck, may secretly be investigating her.
After disobeying the rules of student drop-offs at the front of Juanita's school, Gabrielle makes it her mission to get even with a parent volunteer who banishes her to a faraway parking lot.
Susan is mortified but tries her best to comply when her art teacher asks the students to show up to class in the nude in order to help them create from a point of honesty. In the meantime, Bree serves up some delicious, homemade soup for the homeless at the local shelter, but ends up enticing the local hipsters and pushing out those in need.
Gabrielle must try to move the body of her stepfather with the aid of her friends Lynette and Bree, while Susan notices that her internship is less art-related than she expected. Meanwhile, Lynette feels competitive with Tom's new girlfriend.
Bree is shocked to learn who dug up Gabrielle's stepfather, and Lynette lies to Penny about Tom's new girlfriend. In the meantime, Susan tries to improve her art and impress her teacher, and Gabrielle and Carlos try to change Bob and Lee's opinion of their daughters.
Detective Chuck Vance begins harassing Bree as his suspicions about her involvement in the disappearance of Alejandro grow. After using the cuddle of Gabrielle\'s stepfather as inspiration for her art school projects, Susan must find a way to graciously decline art school teacher Andre\'s invitation to display and sell her paintings at a gallery showing.
Gabrielle goes on a desperate search to find Carlos; a drunk Bree reveals her past and present details, and then goes to a motel room.
After her friends abandon her, Bree prepares to end her life. Meanwhile, Gabrielle think Carlos might have had a hand in another cuddle, and Susan makes a decision about her career, while Lynette makes a confession to her husband Tom.
With Carlos still in rehab, Gaby asks for Lynette's help in wooing a high-stakes company to sign with her husband's firm; Renee talks Bree into getting out of the house and having some fun at a pickup bar; in an attempt to ease her guilt, Susan pays a covert visit to Alejandro's family to see how they've been holding up since he went missing.
Bree's life continues to spiral as her alcohol consumption rises - as does her lust for men; Lynette goes out on her first date since separating with Tom - with Renee's hairdresser; Alejandro's current wife suspects foul play is afoot and has a confrontation with Susan.
Susan is shocked when she learns Julie is six months pregnant, and Bree's life continues to revolve around alcohol and men. Meanwhile, Lynette has a lackluster sexual encounter, and Juanita is upset when she doesn't receive a Valentine's Day card from her crush.
Susan finds out who fathered Julie\'s baby, and Orson vows to nurse Bree back to health. Meanwhile, Gabrielle takes Roy in when Mrs. McCluskey kicks him out, and Porter and Preston try to move back in with Lynette after they are evicted.
Susan tells Porter that she'll set up a nursery and watch over his and Julie's baby after Lynette firmly tells her son that she will not help raise her future granddaughter; Orson convinces Bree to go away with him to the Maine countryside - perhaps never returning to Wisteria Lane; Karen pleads with Gaby not to tell Roy about her condition; and good deeds never go unpunished when, after paying off Ben's loan shark, the thug sets his eyes on destroying Renee's life.
Susan convinces Mike to go to the police when she discovers that Ben's loan shark is out to get him, which could have dire results. Meanwhile, Gabrielle is justifiably concerned when Carlos exhibits some strange behavior on his first day back to work, and Tom's girlfriend, Jane, drops a bombshell on Lynette during Penny's birthday party. In the meantime, Mrs. McCluskey, who is suffering from terminal cancer, asks Bree to help put an end to her life.
On the day of a beloved Wisteria Lane resident's funeral, each of the housewives recalls the effect this person had on her life. Meanwhile, Bree is stunned when she's called in for questioning about the cuddle of Gaby's stepfather, Alejandro.
Julie becomes concerned over Susan's parenting skills when she begins to allow MJ to do whatever he feels like doing. Meanwhile, with Carlos resigning from his high-paying job, Gabrielle tries to land her own high-powered position in order to keep up her extravagant lifestyle. Bree is suspicious of Andrew's intentions when he announces that he's getting married, and Lynette puts a plan into action in the hopes of winning Tom back, while Ben finally properly proposes to Renee.
Susan discovers that Mike had been hiding a secret from her for years; Bree attempts to hire a high-powered attorney when she becomes the prime suspect in the cuddle of Gaby's stepfather; Gaby discovers a sexy way to earn a bigger commission at her new job as a personal shopper; and while Lynette continues to try and win Tom back, girlfriend Jane does everything in her power to ensure that the two carry through with their divorce.
With Mike gone, Susan attempts to build a car for MJ's father-and-son school soapbox derby, while Bree's attorney, Trip Weston, learns of her previous drunken sexual spree and needs her to come clean about it in order to help strengthen her case. Lynette tries to cause some negative friction between Tom and his girlfriend, Jane, by flirting with his boss and getting him to pile more work on her estranged husband. Meanwhile, Gabrielle is furious with Carlos when he tries to poach one of her rich, personal shopper clients and talk her into helping with his newly formed charity organization, and Renee discovers that Ben is keeping a secret from her about his involvement with Bree - and the body found at his work site.
Bree starts to develop feelings for her attorney, Trip Weston. Lynette tries to keep Tom from being transferred to India, and Gabrielle's nonchalant attitude about Bree's trial shocks the ladies.
This is part one of the two-hour Desperate Housewives series finale, as Trip urges Bree to tell him what really happened the night of Alejandro's cuddle.
Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.