The 2012 Ninja Turtles trains the 1987 Ninja Turtles in order to be ready for a dangerous mission to hunt down 1987 Shredder and Krang while April and Casey enlists Karai and Shinigami in order to track down Bebop and Rocksteady.
The turtles emerge from their hidden lair in the sewers for the very first time, ready to confront the wondrous and hostile world of New York City and face enemies more dangerous and pizza more delicious than anything they could have imagined. Along the way, they gain a friend in the fiesty teenage April O'Neil and gain enemies in the form of The Foot, The Shredder, and the alien Kraang.
Funnier and ninja-ier than ever before, the show will explore the camaraderie of four teenage brothers learning to rely on themselves and one another as they unravel the mystery of their existence and grow to become the heroes they are destined to be.