A hospital stay unsettles Malcolm, who's stuck in a kids ward with what may be appendicitis. Meanwhile, at military school, Francis leads a hunger strike.

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Homer "runs" in the Springfield marathon, but when Bart crashes the end of the race an unruly mob is ready to lynch him. A passing stranger rescues him and offers Bart the opportunity to join a new boy band "Party Posse" as the bad boy. Other members of this new band include, Milhouse, Nelson and Ralph. Using NASA technology to enhance their voices they might just make it. And they will, until it is revealed that their videos and music are rigged to brainwash people into joining the Navy. Their manager goes crazy when the government cuts off his funding, but with a little help from N' Sync, the boys of Party Posse try to save the staff of "Mad Magazine" from certain destruction.

Hank's new co-worker is Tammi, a not-too-bright young woman who just moved from Oklahoma. Peggy takes Tammi under her wing and offers to let her stay at the Hill house while she studies to get her GED. Peggy and Hank enjoy Tammi's company and the cool clothes she buys for them, though they're concerned that her dates never seem to last more than an hour. But when Alabaster Jones, the baddest pimp in Oklahoma City, comes to bring Tammi back, Hank finally realizes that Tammi is a hooker and that everybody thinks he's her new pimp.

When Teresa Hoese (the woman Scully and Mulder met the previous spring in Oregon just before Mulder was abducted) is found in a desert after enduring alien testing, Doggett alerts Scully that this could have something to do with Mulder and his whereabouts. Skinner joins them and they travel to the hospital where Teresa is clinging to life by a thread, and Scully realizes that this is exactly what's going on with Mulder.

Debbie is upset that Michael has ended things with David and takes her fury out on Brian, demanding that he give Michael a chance to grow up and have his own life. Brian throws Michael an elaborate surprise 30th birthday party, and then outs him to an unsuspecting Stacy. Michael is hurt and bewildered by Brian's actions, while everyone else is generally disgusted. Ted gets tested when he discovers that one of his encounters is HIV positive. He's negative, but Emmett (who got tested for moral support) is unable to get his results until Monday. Emmett spends the weekend convinced he's positive and makes a pact with God that he'll give up sex with men if the test results are negative. Debbie realizes that Brian's "betrayal" was the push she wanted him to give Michael, and for that she is grateful. Michael asks David if the offer to move in is still open. Emmett finally gets the good news that he is negative.

Hill gets caught in a deliberate attempt to frame him for drug possession. To fight back, he gets some medical info that leads to Supreme's demise. Redding thanks Hill and offers to bring him back to the crew in return. Hill thanks Redding but refuses. The Colonel's attempt to kill Morales backfires. The tides turn on Cloutier who is first stripped of his position in his church and then endures his followers turning against him. After Hughes takes over the solitary ward, Glynn goes in to try and calm him down. Hughes tries to kill Glynn but gets killed himself. Frustrated, hurt and helpless, Glynn transcribes his letter of resignation to his secretary. Murphy offers to be McManus' teammate in the final basketball game. McManus appears on the tv game show and loses in the first round. White gets returned to solitary for starting a fight with other inmates. When McManus confronts him about it, White goes into a rage and stomps McManus. The news of Beecher's parole enrages Schillinger who immediately order's Beecher's murder. Later, Schillinger and Robson try to ambush Beecher in the library only they are shanked by an enraged Said. After talking with his mother, O'Reily decides to change up. He goes to Glynn to warn him of the bomb Connolly plans to detonate. The common room is cleared only for Connolly who holds the bomb as it's timer counts down. The bomb doesn't go off and Connolly's taken by the SORT team. Meanwhile, a guard lights a cigarette in the kitchen causing a major explosion.

Dr. Zoidberg tries his luck as a part time comedian much to the dislike of his audience. He decides to get professional help - his old uncle formerly famous Harold Zoid. Zoid sees no comedy talent lurking within Zoidberg though and decides to go with drama. They get AMC actor Calculon to do a main role by promising him an Oscar.

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