When Earl decides to get his first real job at an appliance store, he experiences 'growing pains'. Meanwhile, Joy makes another irrational decision as her the upcoming trial draws closer.

Lana and Lionel have a secret meeting, after which Lana is shot. While Jimmy is observing photos of the encounter, he is knocked unconscious. While unconscious Jimmy dreams about what life in Smallville would have been like in the 1940s. Clark is a reporter at the Daily Planet, Lana is a siren who planned the demise of her magnate husband Lex, and Lois is a singer at a bar that Lionel owns.

After tribal council, Alex is glad to still be in the game. Alex and Stacy talk and Boo breaks up the conversation. At the reward challenge, the winner would receive a river rafting trip along with an advantage, while the two runners-up would join the winner. Boo won and Yau-Man and Dreamz joined him. At the reward, they enjoy a river rafting trip, then a nice lunch and finally, letters from home. At the immunity challenge, Boo's advantage allowed him to skip to the final round with Dreamz and Alex. In the end, Boo won immunity and could not be voted out. At tribal council, in a 6-1 decision, Alex Angarita, the final member of the Four Horsemen alliance was voted out. Alex also becomes the sixth member of the jury.

Betty struggles with a dilemma as she attempts to bail her family out of a financial crisis while juggling with the task of planning MODE's big assistants week at a medieval-themed restaurant...where Amanda's past ties to the establishment has a link and could come back to haunt her in a surprising way. On the romantic front involving the Meade siblings, Betty tries to give Daniel advice about his endless sexual addiction, while Alexis ponders about whether she should start taking up Rodrigo's offer. Meanwhile, Hilda prepares for her first exam to determine her future at cosmetology school as Wilhelmina prepares for her future plans to take over MODE as she makes even bolder moves for domination behind the scenes.

J.D. tries to get together with Elliot's sorority sister Melody, but she just wants to make out with him without going further.

Keith re-proposes to Elliot after she gets to make everything perfect, while everyone has fantasies about being married to Elliot.

Elliot and Carla are having problems figuring out what is wrong with two elderly patients, who show the same symptoms but have no obvious connection.

Several suspects in a murder case are UFO-club members who believe shape-shifting aliens have been working to conquer the human race for centuries

Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.

Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.

When Phyllis gets an unexpected eyeful from a flasher, Michael decides to take the women of the office on a special outing. Meanwhile, Dwight and Andy work to track down the flasher.

Xzibit and the boys at GAS transform a 1981 Mercedes-Benz 300SE from clunker to "crunker".

An old friend of Stark is back. But this time, Stark gets a second chance at justice when he puts Wayne Callison on trial for another murder. Because of the exact same wounds as the previous victim, Callison is accused of murdering another young woman.

While on the trail of a Djinn, Dean wakes up one night and finds that he is in an alternate reality where Mary never died and John Winchester and his sons never hunted monsters. In this life, Sam is in law school and engaged to Jessica, and Dean has a steady job and a beautiful girlfriend. However, when a strange woman begins following him around , Dean realizes that all of the people that he and Sam saved have died, and has to decide if he wants to stay in his new life or return to reality.

Addison goes on a road trip to LA as she is given another job offer in California, although she finds that no matter where she is, drama follows her. While in LA, she helps resolve a surrogacy problem, where it seems the surrogate had unprotected sex with many other guys on the week she was implanted with the fertilized egg. Meredith continues to improve her relationship with her father and step-mother when her step-mother is brought to the hospital. Cristina is having issues coping with her mother and (soon-to-be) mother-in-law.

Lukas carefully arranged formal dinner for the ER staff gives Abby the surprise of a lifetime when she discovers the real reason for the evening. Luka finds himself dealing with Abbys reaction, but love prevails, and in the end, events come off as planned. As the celebration continues, Pratt plays an important role with a bit of panache, Morris and Hope find themselves with an opportunity they cant resist, and Neela finds herself the center of all manner of unexpected attention.

Penn and Teller look into the Americans with Disabilities Act, which was signed into law in 1990 by the first President Bush.

Gabe Ruediger is picked to fight Corey Hill as Team Penn tries to win their first victory. However, problems arise when Gabe can't cut the necessary pounds for the weigh-ins.

Tonight, journalist Ted Koppel.
Politicians on television programs us common folks watch are prevalent this week as Jon begins the show by looking at President Bush and Laura Bush on American Idol & Hillary Clinton on The Insider. As the 4th anniversary of Bush's mission accomplished on the aircraft carrier fiasco loomed large this week, the Democrats passed the Iraq funding bill only to have it vetoed by Bush in a continuing show segment, "Mess O' Potamac". Finally, snitchin' is not hip in the African-American community. Just ask Cam'ron, a rapper who made it clear that those who snitch to the police about crimes in the community, even a serial killer who lives next door, have no street cred and thus sales of their rap albums suffer. Senior Black Correspondent Larry Wilmore talks with Jon about the ethical implications of this stop snitchin' phenomenon and the rappers code of "effix".

Tonight Stephen welcomes historical novelist and author of The Dangerous Book for Boys, Conn Iggulden.

The popular news quiz returns, with team captains Paul Merton and Ian Hislop, guest host Bill Bailey, and guest panellists Armando Iannucci and Adam Buxton.

Jeremy gets to meet his hero. Mark attends a school reunion and considers having an affair.