Big changes are afoot when Jackie, separated from Kevin, hits rock bottom and realizes she needs professional help, while All Saints is taken over by a corporation whose new director Mike Cruz makes a shocking personnel change. Also, Kevin does not react well when he learns the truth about Jackie and Eddie, and O'Hara reveals a stunning secret.

Jackie detoxes in rehab, where she faces the truth about how her drug dependency began, deals with an unpleasant roommate, and forges a surprising alliance with 17-year-old fellow addict Charlie, who is a rehab veteran despite his tender years; Cruz's innovations continue to irritate everyone on the All Saints staff except for Coop.

Worried about her daughter, Jackie leaves rehab early against her therapist's advice and finds that returning to work greatly rattles her nerves, forcing her to struggle to maintain her sobriety; Zoey has second thoughts about her relationship with Lenny; Eddie tells Jackie that he confessed their affair to Kevin.

Jackie learns that Grace knows the truth about rehab and races to tell Kevin before he hears about it from their daughter, but she gets an unwelcome surprise at Kevin's apartment; Cruz docks Jackie's pay for supplies she stole during his welcome speech; Jackie asks Charlie to meet her at an AA meeting but he shows up drunk.

Jackie invites Kevin to meet her at a cafe but is served divorce papers instead of lunch; Cruz institutes a draconian new dress code that is not a hit with his staff; Zoey looks for a new roommate and finds one in the lonely Jackie.

Jackie has a disturbing dream about using; Coop insists on being involved with O'Hara's child; Zoey loses her engagement ring; O'Hara takes action on Jackie's behalf when Kevin sues for full custody of the kids.

Jackie covers for Cruz when he has a panic attack; Zoey surveys her coworkers for the best ways to conduct a breakup; Akalitus enlists the staff in an elaborate charade when her mentor is admitted with dementia.

Cruz takes revenge on Jackie's coworkers for their history of covering up her addiction; Eddie offers support for Jackie's case during his deposition to Kevin's lawyer; O'Hara finally leans on Coop during an OB/GYN appointment.

Things get out of control in the emergency room due to the recent firings and an overflow of patients who have been diverted from another hospital, causing Cruz to suffer a pulmonary episode and Jackie to step in. At home, a rebellious Grace refuses to go to class unless Jackie transfers her to public school.

Cruz purposely pushes Jackie to the breaking point and uses her reaction as grounds to fire her; Jackie enrolls Grace in public school; O'Hara goes into labor.