Victims of a bus accident are treated; two doctors join the rotation; O'Hara is happy spending time with her son; Akalitus gives Eddie his job back.

Jackie and Kevin are at a stalemate in their divorce mediation because Kevin wants full custody. A patient from the bus crash is back after she contracted sepsis while at All Saints. Coop is angry that he isn't named Chief of the ER and wants to quit but Jackie tells him he'll get respect if he mans up. Jackie, overwhelmed by the day, vents to the only person who will understand - Charlie Cruz.

After their custody meeting, Jackie rear-ends Kevin and wakes up as a patient in her own ER. Kevin accuses her of using. Coop begins covering for Carrie and taking on a lot more work. When Carrie checks on Jackie, she writes her a prescription for Oxy, unaware she's an addict. The most unlikely person asks Jackie out on a date.

A heavily medicated Jane Doe is brought into the ER and Jackie tasks Zoey with finding out who she is. Coop invites Carrie to dinner. Jackie faces conflict with both her daughters - Fiona has been acting out in class while Grace sneaks around the city with her older boyfriend.

Jackie is nervous about her date with Frank, so Zoey and Thor help her get ready and Eddie offers some friendly pointers. Prentiss misdiagnoses an injured dancer, but Akalitus and Coop catch his mistake before the patient leaves. Mike Cruz calls Jackie in a moment of need.

Jackie and Grace both have to recover from their nights of indiscretion. Carrie uses flashcards to strengthen her skills but then cons Coop into doing more of her work anyway. Cruz arrives for his exit interview, putting everyone on edge. Jackie tries to tell Cruz what they did was a mistake, but he won¿t hear any of it.

Akalitus forgets to hire an escort for a psych patient who ends up laying waste to the pharmacy. Frank cancels his lunch date with Jackie because he picked up an extra shift. Zoey hears Coop and Carrie having sex. Jackie worries about Frank when news that a cop has been shot reaches the hospital.

What clearly is going to be "the night" for Jackie and Frank is interrupted by Kevin, figuring she was at work. Kevin is apologetic, but Jackie is angry; Akalitus's blood results are in; Zoey helps Prentiss organize his disaster of an office; In a moment of panic, Carrie makes the right diagnosis on a patient who cannot breathe; Jackie attends an AA meeting; Jackie and Grace get into a fight after Jackie discovers Grace left campus for lunch. Jackie is convinced that Grace is sneaking behind her back to see Danny, but Grace assures her they broke up.

Jackie and Frank have sex for the first time; Akalitus has an extra spring in her step; Coop wants to take his mentoring of Carrie to the next level; Kevin and Grace show up at the hospital after Kevin found a bag of pills in Grace's bag, Jackie delivers Grace to Akalitus and Thor who give her a scared straight tour of the emergency department; Grace has to assist Jackie with a man who collapses on the sidewalk; Jackie wants the girls to live with Kevin.

It's Jackie's one-year anniversary of sobriety; Jackie and Frank fight, He feels he took a big unreciprocated step forward in their relationship, and now he's taking one backward; Wally, an 80 year old gay man with advanced liver cancer is admitted into the hospital. Thor instantly gravitates toward him; Zoey acts very professionally and rigid around Prentiss after their intimate evening; Carrie is notified there will be a peer review of her first few months of residency, Coop pleads for her to stay but Akalitus, Prentiss and Jackie vote against; Wally asks Jackie to administer his last rites; When Zoey learns that Grace isn't going to Jackie's anniversary celebration she rents a car and kidnaps Grace from school, Grace has a breakdown; Jackie nonchalantly takes the pill from her ring box and swallows it, she arrives at her celebration stoned in front of everyone including surprise guest O'Hara who has flown in for the special day.