Buried secrets come to light as Alex treats an elderly patient whose unusual symptoms have her convinced she's living in a different era. Charlie and Joel get competitive as their patients pit their surgeons against each other. And Maggie agrees to shadow Dr. Kalfas for a surgery, but has to take the reins when complications arise.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancee and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life.
As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.